ArticleNucleic acids research1996
The exon sequence TAGG can inhibit splicing.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Mutually exclusive splicing regulates the Nav 1.6 sodium channel function through a combinatorial mechanism that involves three distinct splicing regulatory elements and their ligands.Nucleic acids research · 2012Article
- Combined use of MS2 and PP7 coat fusions shows that TIA-1 dominates hnRNP A1 for K-SAM exon splicing control.Journal of biomedicine & biotechnology · 2009Article
- Regions of the amino terminus of the P2X receptor required for modification by phorbol ester and mGluR1alpha receptors.Journal of neurochemistry · 2009Article
- Multiple and specific mRNA processing targets for the major human hnRNP proteins.Molecular and cellular biology · 2008Article
- Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc.The Journal of biological chemistry · 2008Article
- Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes.Nucleic acids research · 2007Article
- Imaging the alternative silencing of FGFR2 exon IIIb in vivo.RNA (New York, N.Y.) · 2006Article
- Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice.Molecular and cellular biology · 2006Article
- A combinatorial code for splicing silencing: UAGG and GGGG motifs.PLoS biology · 2005Article
- Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts.Molecular and cellular biology · 2003Article
- Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch.The EMBO journal · 2002Article
- 5'- and 3'-terminal nucleotides in the FGFR2 ISAR splicing element core have overlapping roles in exon IIIb activation and exon IIIc repression.Nucleic acids research · 2001Article
- Polypyrimidine tract binding protein antagonizes exon definition.Molecular and cellular biology · 2001Review
- Utilization of the bovine papillomavirus type 1 late-stage-specific nucleotide 3605 3' splice site is modulated by a novel exonic bipartite regulator but not by an intronic purine-rich element.Journal of virology · 2000Article
- An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein.Molecular and cellular biology · 2000Article
- The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site.Molecular and cellular biology · 2000Article
- Article
- Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization.The EMBO journal · 1999Article
- Regulation of fibronectin EDA exon alternative splicing: possible role of RNA secondary structure for enhancer display.Molecular and cellular biology · 1999Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fibroblast growth factor receptor-2 gene contains a pair of alternative exons, K-SAM and BEK, which are spliced in a cell type specific manner. We have shown previously that a 10 nucleotide sequence within the K-SAM exon exerts a negative effect on K-SAM exon splicing independent of cell type. We demonstrate here that this sequence works autonomously, as it can repress splicing of a heterologous exon, the EIIIb alternative exon of the rat fibronectin gene. By introducing point mutations into the 10 nucleotide sequence, we have shown that the functional portion is limited to 4 nucleotides, TAGG, the dinucleotide AG of which is particularly important. This short sequence may participate in the control of splicing of exons carrying it, provided that they carry weak splice sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.