ArticleMolecular and cellular biology1996
Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Mechanisms of Binding Specificity among bHLH Transcription Factors.International journal of molecular sciences · 2021Review
- Regulation of eukaryotic initiation factor 4AII by MyoD during murine myogenic cell differentiation.PloS one · 2014Article
- MyoD directly up-regulates premyogenic mesoderm factors during induction of skeletal myogenesis in stem cells.The Journal of biological chemistry · 2011Article
- Transcriptional regulation of selenoprotein W by MyoD during early skeletal muscle differentiation.The Journal of biological chemistry · 2010Article
- Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming.Developmental cell · 2010Article
- The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function.PLoS genetics · 2008Article
- Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters.The EMBO journal · 2006Article
- Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway.The Journal of biological chemistry · 2006Article
- Functional interaction between peroxisome proliferator-activated receptors-alpha and Mef-2C on human carnitine palmitoyltransferase 1beta (CPT1beta) gene activation.Nucleic acids research · 2004Article
- The role of basal and myogenic factors in the transcriptional activation of utrophin promoter A: implications for therapeutic up-regulation in Duchenne muscular dystrophy.Nucleic acids research · 2001Article
- Overlapping expression of early B-cell factor and basic helix-loop-helix proteins as a mechanism to dictate B-lineage-specific activity of the lambda5 promoter.Molecular and cellular biology · 2000Article
- Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations.Molecular and cellular biology · 2000Article
- Intramolecular regulation of MyoD activation domain conformation and function.Molecular and cellular biology · 1998Article
- The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist.Molecular and cellular biology · 1997Article
- Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A method has been developed for selecting functional enhancer/promoter sites from random DNA sequences in higher eukaryotic cells. Of sequences that were thus selected for transcriptional activation by the muscle-specific basic helix-loop-helix protein MyoD, only a subset are similar to the preferred in vitro binding consensus, and in the same promoter context an optimal in vitro binding site was inactive. Other sequences with full transcriptional activity instead exhibit sequence preferences that, remarkably, are generally either identical or very similar to those found in naturally occurring muscle-specific promoters. This first systematic examination of the relation between DNA binding and transcriptional activation by basic helix-loop-helix proteins indicates that binding per se is necessary but not sufficient for transcriptional activation by MyoD and implies a requirement for other DNA sequence-dependent interactions or conformations at its binding site.
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