ArticleMolecular and cellular biology1996
The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
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- Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells.International journal of molecular sciences · 2022Article
- The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency.Development (Cambridge, England) · 2021Article
- The transcription factors SF-1 and SOX8 cooperate to upregulateBiochemistry and biophysics reports · 2020Article
- A T > G Mutation in theFrontiers in genetics · 2019Article
- Rethinking Bile Acid Metabolism and Signaling for Type 2 Diabetes Treatment.Current diabetes reports · 2018Review
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- Associations of NR5A2 gene polymorphisms with the clinicopathological characteristics and survival of gastric cancer.International journal of molecular sciences · 2014Article
- Differentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cells.World journal of stem cells · 2014Review
- The orphan nuclear receptors at their 25-year reunion.Journal of molecular endocrinology · 2013Review
- Article
- The LIM domain protein FHL2 interacts with the NR5A family of nuclear receptors and CREB to activate the inhibin-α subunit gene in ovarian granulosa cells.Molecular endocrinology (Baltimore, Md.) · 2012Article
- The EIIAPA chimeric promoter for tumor specific gene therapy of hepatoma.Molecular imaging and biology · 2012Article
- Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest.Journal of transplantation · 2012Article
- Emerging actions of the nuclear receptor LRH-1 in the gut.Biochimica et biophysica acta · 2011Review
- Identification of two functional nuclear localization signals mediating nuclear import of liver receptor homologue-1.Cellular and molecular life sciences : CMLS · 2011Article
- Zhx2 and Zbtb20: novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer.Seminars in cancer biology · 2011Review
- Molecular cloning and expression analysis of fushi tarazu factor 1 in the brain of air-breathing catfish, Clarias gariepinus.PloS one · 2011Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The alpha1-fetoprotein (AFP) gene is located between the albumin and alpha-albumin genes and is activated by transcription factor FTF (fetoprotein transcription factor), presumed to transduce early developmental signals to the albumin gene cluster. We have identified FTF as an orphan nuclear receptor of the Drosophila FTZ-F1 family. FTF recognizes the DNA sequence 5'-TCAAGGTCA-3', the canonical recognition motif for FTZ-F1 receptors. cDNA sequence homologies indicate that rat FTF is the ortholog of mouse LRH-1 and Xenopus xFF1rA. Rodent FTF is encoded by a single-copy gene, related to the gene encoding steroidogenic factor 1 (SF-1). The 5.2-kb FTF transcript is translated from several in-frame initiator codons into FTF isoforms (54 to 64 kDa) which appear to bind DNA as monomers, with no need for a specific ligand, similar KdS (approximately equal 3 x 10(-10) M), and similar transcriptional effects. FTF activates the AFP promoter without the use of an amino-terminal activation domain; carboxy-terminus-truncated FTF exerts strong dominant negative effects. In the AFP promoter, FTF recruits an accessory trans-activator which imparts glucocorticoid reactivity upon the AFP gene. FTF binding sites are found in the promoters of other liver-expressed genes, some encoding liver transcription factors; FTF, liver alpha1-antitrypsin promoter factor LFB2, and HNF-3beta promoter factor UF2-H3beta are probably the same factor. FTF is also abundantly expressed in the pancreas and may exert differentiation functions in endodermal sublineages, similar to SF-1 in steroidogenic tissues. HepG2 hepatoma cells seem to express a mutated form of FTF.
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