ArticleThe Journal of experimental medicine1996
Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 82 citations in OpenAlex.
- Leukotriene inhibitors in multiple sclerosis: a systematic review of animal studies.Inflammopharmacology · 2026Article
- Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges.Drug delivery and translational research · 2024Review
- Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than ReportedMetabolites · 2021Article
- Intracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticles.Materials (Basel, Switzerland) · 2019Article
- Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells.Frontiers in molecular neuroscience · 2019Article
- The role of the LTBSeminars in immunology · 2017Review
- Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling.Journal of lipid research · 2017Article
- G protein-coupled receptors as therapeutic targets for multiple sclerosis.Cell research · 2012Review
- The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: assessment of eosinophil degranulation ex vivo and in models of human disease.Journal of immunological methods · 2012Article
- Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Mast cell regulation of the immune response.The World Allergy Organization journal · 2009Article
- Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats.Immunology · 2008Article
- Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.The Journal of experimental medicine · 2005Article
- Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection.Infection and immunity · 2002Article
- Acute neuronal apoptosis in a rat model of multiple sclerosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis.The Journal of experimental medicine · 2000Article
- Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils.The Journal of experimental medicine · 1998Article
- Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins.The Journal of clinical investigation · 1997Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukotriene B4 (LTB4) is a chemotactic and cell-activating factor present at inflammatory sites in a variety of autoimmune diseases including multiple sclerosis (MS). In this study, we used a murine model of MS, experimental allergic encephalomyelitis (EAE), to assess the potential role of LTB4 on cell infiltration and paralysis. Injection of encephalogenic T cells into naive animals induced paralysis and weight loss that was completely inhibited by treatment with the selective LTB4 receptor antagonist CP-105,696 (ED50= 8.6 mg/kg orally). Although migration of lymphocytes into the central nervous system was unaffected, the efficacious effects of CP-105,696 correlated with up to a 97% decrease in eosinophil infiltration into the lower spinal cord as determined by light and electron microscopy and quantitated by levels of the specific enzyme marker eosinophil peroxidase. These results demonstrate that eosinophil recruitment in EAE is dependent on LTB4 receptor ligation and further reveal a previously unrecognized role for eosinophils in the pathogenesis of this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.