ArticleThe Journal of experimental medicine1996
The interaction of macrophage and non-macrophage tropic isolates of HIV-1 with thymic and tonsillar dendritic cells in vitro.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- HIV-exposed uninfected children: a growing population with a vulnerable immune system?Clinical and experimental immunology · 2014Review
- Review
- Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro.Retrovirology · 2011Article
- HIV-1 infection inhibits cytokine production in human thymic macrophages.Experimental hematology · 2010Article
- Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytes.Journal of virology · 2007Article
- Cytokine-adjuvanted HIV-DNA vaccination strategies.Springer seminars in immunopathology · 2006Review
- Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes.The Journal of clinical investigation · 2005Article
- Complementary antiviral efficacy of hydroxyurea and protease inhibitors in human immunodeficiency virus-infected dendritic cells and lymphocytes.Journal of virology · 2002Article
- CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor.Journal of virology · 2000Article
- Thymic dendritic cells are primary targets for the oncogenic virus SL3-3.Journal of virology · 1998Article
- Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to T cells.Journal of virology · 1998Article
- Naïve and memory CD4 T cells differ in their susceptibilities to human immunodeficiency virus type 1 infection following CD28 costimulation: implicatip6s for transmission and pathogenesis.Journal of virology · 1998Article
- HIV-1 selection by epidermal dendritic cells during transmission across human skin.The Journal of experimental medicine · 1998Article
- Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection.Nature medicine · 1997Article
- Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection.The American journal of pathology · 1997Article
- Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells.The Journal of experimental medicine · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells isolated from thymus and tonsil were tested for susceptibility to HIV-1 strains that are tropic for macrophages or for T cell lines. DCs were purified by cell sorting and before infection expressed high levels of CD4 and HLA-DR and lacked markers for T, B, NK cells, or macrophages. Viral entry and reverse transcription was found after pulsing with strains of HIV-1 that could infect macrophages. During the first 36 h the PCR signals for gag sequences increased in DCs and macrophages. In contrast little if any viral DNA was found after pulsing macrophages or DCs with HIV-1 that was able to infect T cell lines. DCs pulsed with HIV-1 were able to transmit infection to responding T cells during an allogeneic or superantigen response. Selection for virus able to infect lymphoid DCs and other DCs expressing CD4 and its transfer to T cells during subsequent immune responses may provide a mechanism for the observed predominance of macrophage-tropic HIV-1 after in vivo transmission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.