ArticleThe Journal of cell biology1996
Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 204 citations in OpenAlex.
- Transcriptome Sequencing of LYPLA1 Gene Overexpression and Interference.Animals : an open access journal from MDPI · 2026Article
- Ninein isoform contributions to intracellular processes and macrophage immune function.The Journal of biological chemistry · 2025Article
- Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice.eLife · 2025Article
- Article
- Emerging mechanisms of dynein transport in the cytoplasm versus the cilium.Biochemical Society transactions · 2018Review
- Fluorescence microscopy applied to intracellular transport by microtubule motors.Journal of biosciences · 2018Review
- Characterization and genomic structure of Dnah9, and its roles in nodal signaling pathways in the Japanese flounder (Paralichthys olivaceus).Fish physiology and biochemistry · 2016Article
- Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity.ACS chemical biology · 2016Article
- Dynein and intraflagellar transport.Experimental cell research · 2015Review
- Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures.Cell & bioscience · 2015Article
- A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.Journal of cell science · 2013Article
- Unconventional functions of microtubule motors.Archives of biochemistry and biophysics · 2012Review
- Cell polarity as a regulator of cancer cell behavior plasticity.Annual review of cell and developmental biology · 2012Review
- A role for Tctex-1 (DYNLT1) in controlling primary cilium length.European journal of cell biology · 2011Article
- Golgi positioning.Cold Spring Harbor perspectives in biology · 2011Review
- The cilia protein IFT88 is required for spindle orientation in mitosis.Nature cell biology · 2011Article
- Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development.Neural development · 2010Article
- Discovery of the mitotic selective chromatid segregation phenomenon and its implications for vertebrate development.Current opinion in cell biology · 2010Review
- Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity.The EMBO journal · 2010Article
- Cytoskeletal mechanisms for breaking cellular symmetry.Cold Spring Harbor perspectives in biology · 2010Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We describe two dynein heavy chain (DHC)-like polypeptides (DHCs 2 and 3) that are distinct from the heavy chain of conventional cytoplasmic dynein (DHC1) but are expressed in a variety of mammalian cells that lack axonemes. DHC2 is a distant member of the "cytoplasmic" branch of the dynein phylogenetic tree, while DHC3 shares more sequence similarity with dynein-like polypeptides that have been thought to be axonemal. Each cytoplasmic dynein is associated with distinct cellular organelles. DHC2 is localized predominantly to the Golgi apparatus. Moreover, the Golgi disperses upon microinjection of antibodies to DHC2, suggesting that this motor is involved in establishing proper Golgi organization. DCH3 is associated with as yet unidentified structures that may represent transport intermediates between two or more cytoplasmic compartments. Apparently, specific cytoplasmic dyneins, like individual members of the kinesin superfamily, play unique roles in the traffic of cytomembranes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.