ArticleImmunology1996
Role of virus-specific CD4+ cytotoxic T cells in recovery from mouse hepatitis virus infection.
Article in Immunology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- LY6E impairs coronavirus fusion and confers immune control of viral disease.Nature microbiology · 2020Article
- Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection.Experimental neurology · 2010Article
- Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis.Journal of virology · 2008Article
- Priming of CD8+ T cells during central nervous system infection with a murine coronavirus is strain dependent.Journal of virology · 2008Article
- Mouse hepatitis virus infection of the CNS: a model for defense, disease, and repair.Frontiers in bioscience : a journal and virtual library · 2008Article
- CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.Journal of virology · 2008Article
- CD4+ T-cell responses are required for clearance of West Nile virus from the central nervous system.Journal of virology · 2006Article
- Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals.Journal of neuroimmunology · 2004Article
- Murine hepatitis virus--a model for virus-induced CNS demyelination.Journal of neurovirology · 2002Review
- T-cell receptor-mediated anergy of a human immunodeficiency virus (HIV) gp120-specific CD4(+) cytotoxic T-cell clone, induced by a natural HIV type 1 variant peptide.Journal of virology · 2000Article
- Bystander target cell lysis and cytokine production by dengue virus-specific human CD4(+) cytotoxic T-lymphocyte clones.Journal of virology · 1999Article
- Natural pathogens of laboratory mice, rats, and rabbits and their effects on research.Clinical microbiology reviews · 1998Review
- Role of spleen macrophages in innate and acquired immune responses against mouse hepatitis virus strain A59.Immunology · 1997Article
- Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis.Journal of virology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophages and T lymphocytes play an important role in recovery from viral infections. During mouse hepatitis virus (MHV-A59) infection, a clear virus-specific class II-restricted cytotoxic T-cell response is generated. Transfer of these CD4+ cytotoxic T cells (CTL) into naive mice protects against a lethal challenge with MHV. However, their in vivo antiviral effector mechanism is not yet clear. To further investigate a possible effector mechanism, we studied the effect of adoptive transfer of CD4+ CTL on virus localization in spleen and liver. We showed that adoptive transfer of virus-specific T cells does not affect localization of MHV-A59 in different macrophage subsets. Interestingly, a rapid and large infiltrate of CD4+ T cells in and around MHV-A59-infected foci in the liver was observed early in infection, whereas no CD8+ T cells were detectable. Moreover, transfer of virus-specific T cells resulted in significantly decreased viral titres in the liver and spleen and a marginally increased anti-MHV-A59 IgM production. These results imply an important role for virus-specific CD4+ CTL in elimination of infectious MHV-A59 and induction of an effective immune response in the absence of CD8+ CTL.
Indexed as
Identifiers
8666433PMC1383965W243916314What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.