ArticleThe EMBO journal1996
Immunoglobulin gene hyperconversion ongoing in chicken splenic germinal centers.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 102 citations in OpenAlex.
- Article
- Extrafollicular and Other Non-Germinal Center B Cell Responses: An Evolutionary Perspective.Immunological reviews · 2025Review
- The immune system of chicken and its response to H9N2 avian influenza virus.The veterinary quarterly · 2023Review
- IgY Antibodies from Birds: A Review on Affinity and Avidity.Animals : an open access journal from MDPI · 2023Review
- Expression of ayu antimicrobial peptide genes after LPS stimulation.The Journal of veterinary medical science · 2017Article
- A double-strand break can trigger immunoglobulin gene conversion.Nucleic acids research · 2017Article
- A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation.Frontiers in immunology · 2015Article
- Evolution of B cell immunity.Annual review of animal biosciences · 2013Review
- Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate.PLoS biology · 2004Article
- Insight into lymphoid development by gene expression profiling of avian B cells.Immunogenetics · 2003Article
- Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells.The Journal of experimental medicine · 1998Article
- The antigen-binding characteristics of mAbs derived from in vivo priming of avian B cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been believed that the peripheral lymphocytes in chickens proliferate by self-renewing amplification of the preimmune repertoire generated in bursa. We amplified rearranged immunoglobulin variable (V) region genes from the single germinal centers induced by immunization. The sequence analysis of these genes revealed that most were derived from distinct B-cell clones which expanded locally, generating somatic antibody mutants at a high rate. Somatic hypermutations included unlinked base changes and the linked base modifications interpreted as unidirectional transfer of sequences from V region pseudogenes. This finding demonstrates the ongoing post-bursal diversification of B-cells in splenic germinal centers by templated gene conversion as well as untemplated point mutations.
Indexed as
Identifiers
8665861PMC450186W82827365What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.