ArticleThe EMBO journal1996
Cell cycle-controlled proteolysis of a flagellar motor protein that is asymmetrically distributed in the Caulobacter predivisional cell.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed.
- To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility.Molecular microbiology · 2026Review
- Influence of the Heme Nitric Oxide/Oxygen Binding Protein (H-NOX) on Cell Cycle Regulation in Caulobacter crescentus.Molecular & cellular proteomics : MCP · 2023Article
- Article
- Flagellar Structures from the Bacterium Caulobacter crescentus and Implications for PhageJournal of bacteriology · 2021Article
- Functional Regulators of Bacterial Flagella.Annual review of microbiology · 2019Review
- In situ imaging of the bacterial flagellar motor disassembly and assembly processes.The EMBO journal · 2019Article
- Article
- Cohesive Properties of themBio · 2017Article
- Phosphotransferase-dependent accumulation of (p)ppGpp in response to glutamine deprivation in Caulobacter crescentus.Nature communications · 2016Article
- A NAD-dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus.The EMBO journal · 2015Article
- Regulated proteolysis in bacterial development.FEMS microbiology reviews · 2014Review
- Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle.PLoS genetics · 2013Article
- Flagellin redundancy in Caulobacter crescentus and its implications for flagellar filament assembly.Journal of bacteriology · 2011Article
- Structure of the cytoplasmic domain of the flagellar secretion apparatus component FlhA from Helicobacter pylori.The Journal of biological chemistry · 2010Article
- Getting in the loop: regulation of development in Caulobacter crescentus.Microbiology and molecular biology reviews : MMBR · 2010Review
- Hydrophobic carboxy-terminal residues dramatically reduce protein levels in the haloarchaeon Haloferax volcanii.Microbiology (Reading, England) · 2010Article
- Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression.Genes & development · 2009Article
- Genetic tools for studying Capnocytophaga canimorsus.Applied and environmental microbiology · 2008Article
- SpoT regulates DnaA stability and initiation of DNA replication in carbon-starved Caulobacter crescentus.Journal of bacteriology · 2008Article
- Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.Cell · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Flagellar biogenesis and release are developmental events tightly coupled to the cell cycle of Caulobacter crescentus. A single flagellum is assembled at the swarmer pole of the predivisional cell and is released later in the cell cycle. Here we show that the MS-ring monomer FliF, a central motor component that anchors the flagellum in the cell membrane, is synthesized only in the predivisional cell and is integrated into the membrane at the incipient swarmer cell pole, where it initiates flagellar assembly. FliF is proteolytically turned over during swarmer-to-stalked cell differentiation, coinciding with the loss of the flagellum, suggesting that its degradation is coupled to flagellar release. The membrane topology of FliF was determined and a region of the cytoplasmic C-terminal domain was shown to be required for the interaction with a component of the motor switch. The very C-terminal end of FliF contains a turnover determinant, required for the cell cycle-dependent degradation of the MS-ring. The cell cycle-dependent proteolysis of FliF and the targeting of FliF to the swarmer pole together contribute to the asymmetric localization of the MS-ring in the predivisional cell.
Indexed as
Identifiers
8665847PMC450171What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.