ReviewClinical microbiology reviews1996
Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease.
Review in Clinical microbiology reviews, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 202 citations in OpenAlex.
- Immunopathogenesis and Therapeutics of Systemic Lupus Erythematosus: an Integrative Review.Clinical reviews in allergy & immunology · 2025Review
- Article
- Article
- Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event.PLoS pathogens · 2020Article
- Characterization and mutagenesis of Chinese hamster ovary cells endogenous retroviruses to inactivate viral particle release.Biotechnology and bioengineering · 2020Article
- The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells.PloS one · 2019Article
- Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Inherently variable responses to glucocorticoid stress among endogenous retroviruses isolated from 23 mouse strains.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Human endogenous retroviruses and chosen disease parameters in morphea.Postepy dermatologii i alergologii · 2017Article
- Effects of UVA1 Phototherapy on Expression of Human Endogenous Retroviral Sequence (HERV)-K10 gag in Morphea: A Preliminary Study.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis.Biochimica et biophysica acta · 2016Article
- Historical review of the causes of cancer.World journal of clinical oncology · 2016Review
- Article
- Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?International journal of cancer · 2015Review
- Noncoding RNAs and chronic inflammation: Micro-managing the fire within.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- The placental protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza.PloS one · 2015Article
- Extracellular vesicles in luminal fluid of the ovine uterus.PloS one · 2014Article
- Identification of late assembly domains of the human endogenous retrovirus-K(HML-2).Retrovirology · 2013Article
- Retroviruses and amyotrophic lateral sclerosis.Antiviral research · 2013Review
- Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?Retrovirology · 2013Review
Corrections and comments
- Commented on by
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retroviral diagnostics have become standard in human laboratory medicine. While current emphasis is placed on the human exogenous viruses (human immunodeficiency virus and human T-cell leukemia virus), evidence implicating human endogenous retroviruses (HERVs) in various human disease entities continues to mount. Literature on the occurrence of HERVs in human tissues and cells was analyzed. Substantial evidence documents that retrovirus particles were clearly demonstrable in various tissues and cells in both health and disease and were abundant in the placenta and that their occurrence could be implicated in some of the reproductive diseases. The characteristics of HERVs are summarized, mechanisms of replication and regulation are outlined, and the consistent hormonal responsiveness of HERVs is noted. Clear evidence implicating HERV gene products as participants in glomerulonephritis in some cases of systemic lupus erythematosus is adduced. Data implicating HERVs as etiologic factors in reproductive diseases, in some of the autoimmune diseases, in some forms of rheumatoid arthritis and connective tissue disease, in psoriasis, and in some of the inflammatory neurologic diseases are reviewed. The current major needs are to improve methods for HERV detection, to identify the most appropriate HERV prototypes, and to develop diagnostic reagents so that the putative biologic and pathologic roles of HERVs can be better evaluated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.