ArticleMammalian genome : official journal of the International Mammalian Genome Society1996
GNAI3, GNAT2, AMPD2, GSTM are clustered in 120 kb of Chinese hamster chromosome 1q.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Overexpression of AMPD2 indicates poor prognosis in colorectal cancer patientsWorld journal of clinical cases · 2020Review
- MicroRNA expression signature of methamphetamine use and addiction in the rat nucleus accumbens.Metabolic brain disease · 2017Article
- Structural and functional analysis of four non-coding Y RNAs from Chinese hamster cells: identification, molecular dynamics simulations and DNA replication initiation assays.BMC molecular biology · 2016Article
- oriGNAI3: a narrow zone of preferential replication initiation in mammalian cells identified by 2D gel and competitive PCR replicon mapping techniques.Nucleic acids research · 1998Article
- Twelve genes, including the unassigned proteasome zeta subunit gene, ordered within the human 1p13 region.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- The loop pattern of chromosomal DNA may significantly differ in AT-rich and GC-rich isochores.Doklady. Biochemistry and biophysicsArticle
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6 authors at 2 institutions in 1 country.
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Abstract
We studied a polygenic region located on Chromosome (Chr) 1q in Chinese hamster cells that is coamplified along with the AMPD2 gene. Previous sequence analysis identified both members of the GSTM family and the GNAI3 gene within a cloned 120-kb region surrounding the AMPD2 locus. We show here that the GNAT2 gene, which is inactive in the fibroblastic cells, lies within the 20 kb separating the transcriptionally active GNAI3 and AMPD2 genes. We map most gene ends by sequence comparison with human homologs; one is inferred from the presence of an unmethylated CpG island. This Chinese hamster locus corresponds to a region of conserved linkage between human Chr 1 (locus 1p13) and mouse Chr 3 (position 52.5 cM), where Gnai-3 and Gnat-2 have been mapped. The AMPD2 gene is presently unlocalized in human genome; its proposed position on mouse Chr 3 is at 53.4 cM. Our results, obtained by physical mapping, strongly suggest that the order and possibly the tight linkage of these genes are conserved on all three genomes.
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