ArticleImmunogenetics1996
Expressed Peromyscus maniculatus (Pema) MHC class I genes: evolutionary implications and the identification of a gene encoding a Qa1-like antigen.
Article in Immunogenetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Major histocompatibility complex class I diversity limits the repertoire of T cell receptors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Structure and expression of MHC class Ib genes of the central M region in rat and mouse: M4, M5, and M6.Immunogenetics · 2008Article
- Regulatory T cell-like responses in deer mice persistently infected with Sin Nombre virus.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Profiling helper T cell subset gene expression in deer mice.BMC immunology · 2006Article
- The orthology of HLA-E and H2-Qa1 is hidden by their concerted evolution with other MHC class I molecules.Biology direct · 2006Article
- Polymorphism and conservation of the genes encoding Qa1 molecules.Immunogenetics · 2004Article
- Generation of competent bone marrow-derived antigen presenting cells from the deer mouse (Peromyscus maniculatus).BMC immunology · 2004Article
- Cloning and characterization of deer mouse (Peromyscus maniculatus) cytokine and chemokine cDNAs.BMC immunology · 2004Article
- Sequence, expression, and polymorphism of the Peromyscus leucopus Mhc class Ib gene, M4.Immunogenetics · 2003Article
- Qa-1b binds conserved class I leader peptides derived from several mammalian species.The Journal of experimental medicine · 1998Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To gain insight into the evolution of rodent major histocompatibility complex (MHC) class I genes and identify important (conserved) nonclassical class I (class I b) gene products and residues in these proteins, six Peromyscus maniculatus MHC (Pema) class I cDNA clones were isolated and sequenced. Five Pema class I cDNAs appeared most similar to mouse and rat classical class I (class I a) genes. One exhibited highest similarity to an H2 class I b gene, H2-T23 (encoding the Qa1 antigen). Phylogenetic trees constructed with Pema, RT1, and H2 class I sequences suggested that the lineages of some rodent class I b genes (e. g., T23 and T24) originated prior to Mus and Peromyscus speciation [>50 million years (My) ago]. Sequences of four Qa1-like proteins from three species permitted the identification of ten Qa1-specific amino acids. On the basis of molecular modeling, three residues showed the potential to interact with T-cell receptors and three residues (all corresponding to polymorphic positions among H2 class I a proteins) were predicted to influence antigen binding. The recognition of mouse Qa1 proteins by a subset of T-cells in influenced by a locus, Qdm, which encodes the H2-D leader peptide. One of the Pema class I cDNA clones classified as H2-K, D/L-like (class I a) is predicted to encode an identical peptide, implying that an antigen binding protein (Qa1) and the antigen to which it binds (the product of Qdm) has been conserved for over 50 My.
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