ArticleJournal of molecular evolution1996
Evolutionary relationship of HLA-DRB genes inferred from intron sequences.
Article in Journal of molecular evolution, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Article
- The Primate Major Histocompatibility Complex: A Case Study of Gene Family Evolution.bioRxiv : the preprint server for biology · 2025Article
- Similar patterns of genetic diversity and linkage disequilibrium in Western chimpanzees (Pan troglodytes verus) and humans indicate highly conserved mechanisms of MHC molecular evolution.BMC evolutionary biology · 2020Article
- Complete nucleotide sequence characterization of DRB5 alleles reveals a homogeneous allele group that is distinct from other DRB genes.Human immunology · 2019Article
- Genome and Phylogenetic Analysis of Genes Involved in the Immune System ofFrontiers in genetics · 2019Article
- Current perspectives on the intensity of natural selection of MHC loci.Immunogenetics · 2013Article
- Evolution of HLA-DRB genes.Molecular biology and evolution · 2012Article
- The research of W.E. Mayer (1953-2012): a spectrum of immune systems.Immunogenetics · 2012Review
- Impact of endogenous intronic retroviruses on major histocompatibility complex class II diversity and stability.Journal of virology · 2008Article
- Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles.Immunogenetics · 2007Article
- Owl monkey MHC-DRB exon 2 reveals high similarity with several HLA-DRB lineages.Immunogenetics · 2006Article
- Primate spondyloarthropathy.Current rheumatology reports · 2005Review
- Genomic organization and evolutionary analysis of Ly49 genes encoding the rodent natural killer cell receptors: rapid evolution by repeated gene duplication.Immunogenetics · 2004Article
- A comparison of intraspecific patterns of DNA sequence variation in mitochondrial DNA, alpha-enolase, and MHC class II B loci in auklets (Charadriiformes: Alcidae).Journal of molecular evolution · 2003Article
- Evolutionary instability of the major histocompatibility complex class I loci in New World primates.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Ancestral polymorphism of Mhc class II genes in mice: implications for balancing selection and the mammalian molecular clock.Genetics · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major histocompatibility complex (Mhc) consists of class I and class II genes. In the human Mhc (HLA) class II genes, nine DRB loci have been identified. To elucidate the origin of these duplicated loci and allelic divergences at the most polymorphic DRB1 locus, introns 4 and 5 as well as the 3' untranslated region (altogether approximately 1,000 base pairs) of seven HLA-DRB loci, three HLA-DRB1 alleles, and nine nonhuman primate DRB genes were examined. It is shown that there were two major diversification events in HLA-DRB genes, each involving gene duplications and allelic divergences. Approximately 50 million years (my) ago, DRB1*04 and an ancestor of the DRB1*03 cluster (DRB1*03, DRB1*15, and DRB3) diverged from each other and DRB5, DRB7, DRB8, and an ancestor of the DRB2 cluster (DRB2, DRB4, and DRB6) arose by gene duplication. Later, about 25 my ago, DRB1*15 diverged from DRB1*03, and DRB3 was duplicated from DRB1*03. Then, some 20 my ago, the lineage leading to the DRB2 cluster produced two new loci, DRB4 and DRB6. The DRB1*03 and DRB1*04 allelic lineages are extraordinarily old and have persisted longer than some duplicated genes. The orthologous relationships of DRB genes between human and Old World monkeys are apparent, but those between Catarrhini and New World monkeys are equivocal because of a rather rapid expansion and contraction of primate DRB genes by duplication and deletion.
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