ArticleJournal of molecular evolution1996
Strong evolutionary conservation of broadly expressed protein isoforms in the troponin I gene family and other vertebrate gene families.
Article in Journal of molecular evolution, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 86 citations in OpenAlex.
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- Evolutionary Consequences of DNA Methylation in a Basal Metazoan.Molecular biology and evolution · 2016Article
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- Evolution of vertebrate tissues driven by differential modes of gene duplication.DNA research : an international journal for rapid publication of reports on genes and genomes · 2012Article
- The odds of duplicate gene persistence after polyploidization.BMC genomics · 2011Article
- Comparative network analysis reveals that tissue specificity and gene function are important factors influencing the mode of expression evolution in Arabidopsis and rice.Plant physiology · 2011Article
- Developmental decoupling of alternative phenotypes: insights from the transcriptomes of horn-polyphenic beetles.Evolution; international journal of organic evolution · 2011Article
- Gene discovery in the horned beetle Onthophagus taurus.BMC genomics · 2010Article
- Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.Physiological genomics · 2010Article
- Differential selective constraints shaping codon usage pattern of housekeeping and tissue-specific homologous genes of rice and arabidopsis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2008Article
- Patterns of positive selection in six Mammalian genomes.PLoS genetics · 2008Article
- Do Alu repeats drive the evolution of the primate transcriptome?Genome biology · 2008Article
- Gender-specific selection on codon usage in plant genomes.BMC genomics · 2007Article
- The two AGPase subunits evolve at different rates in angiosperms, yet they are equally sensitive to activity-altering amino acid changes when expressed in bacteria.The Plant cell · 2007Article
- Rate of evolution in brain-expressed genes in humans and other primates.PLoS biology · 2007Article
- The monosaccharide transporter gene family in land plants is ancient and shows differential subfamily expression and expansion across lineages.BMC evolutionary biology · 2006Article
- Accelerated evolutionary rate may be responsible for the emergence of lineage-specific genes in ascomycota.Journal of molecular evolution · 2006Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
It is well established that different protein classes undergo molecular evolution at different rates, presumably reflecting differing functional constraints. However, it is also the case that different isoforms of the "same" protein, encoded by a multigene family, may evolve at different rates. Here I report a relationship within gene families between isoform evolutionary rate and gene expression profile: Broadly expressed isoforms show stronger sequence conservation than do narrowly expressed isoforms. This observation emerged initially from cDNA cloning and sequencing studies, described here, of a vertebrate gene family encoding three differentially expressed isoforms of the muscle protein troponin I. However, the expression breadth/sequence conservation relationship applies to vertebrate gene families in general. In a broad and arbitrary survey sampling of sequence data on well-characterized vertebrate gene families, I found that in 14/15 families the most strongly conserved isoform was the most broadly expressed isoform, or one of several similarly broadly expressed isoforms. Broadly expressed isoforms are presumably subjected to greater negative selection pressure because they must function in a more diverse biochemical environment than do narrowly expressed isoforms. The expression breadth/evolutionary rate relationship has several interesting implications regarding the overall process of gene family evolution by duplication/divergence from ancestral genes.
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