ArticleJournal of molecular evolution1996
Codon usage and base composition in Rickettsia prowazekii.
Article in Journal of molecular evolution, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The effect of the genomic GC content bias of prokaryotic organisms on the secondary structures of their proteins.PloS one · 2023Article
- Bioinformatic Assessment of Factors Affecting the Correlation between Protein Abundance and Elongation Efficiency in Prokaryotes.International journal of molecular sciences · 2022Article
- Patterns of synonymous codon usage on human metapneumovirus and its influencing factors.Journal of biomedicine & biotechnology · 2012Article
- Single-stranded genomic architecture constrains optimal codon usage.Bacteriophage · 2011Article
- Characterizing the native codon usages of a genome: an axis projection approach.Molecular biology and evolution · 2011Article
- Evidence that mutation is universally biased towards AT in bacteria.PLoS genetics · 2010Article
- Codon Usage Patterns in Corynebacterium glutamicum: Mutational Bias, Natural Selection and Amino Acid Conservation.Comparative and functional genomics · 2010Article
- Comparison of correspondence analysis methods for synonymous codon usage in bacteria.DNA research : an international journal for rapid publication of reports on genes and genomes · 2008Article
- Evolutionary constraints on codon and amino acid usage in two strains of human pathogenic actinobacteria Tropheryma whipplei.Journal of molecular evolution · 2006Article
- Protein evolutionary rates correlate with expression independently of synonymous substitutions in Helicobacter pylori.Journal of molecular evolution · 2006Article
- Sca1, a previously undescribed paralog from autotransporter protein-encoding genes in Rickettsia species.BMC microbiology · 2006Article
- Codon usage bias and tRNA over-expression in Buchnera aphidicola after aromatic amino acid nutritional stress on its host Acyrthosiphon pisum.Nucleic acids research · 2006Article
- Analysis of fluorescent protein expression in transformants of Rickettsia monacensis, an obligate intracellular tick symbiont.Applied and environmental microbiology · 2005Article
- Differences in codon bias cannot explain differences in translational power among microbes.BMC bioinformatics · 2005Article
- Variation in the strength of selected codon usage bias among bacteria.Nucleic acids research · 2005Article
- Relative predicted protein levels of functionally associated proteins are conserved across organisms.Nucleic acids research · 2005Article
- Accelerated evolution associated with genome reduction in a free-living prokaryote.Genome biology · 2005Article
- Shannon information theoretic computation of synonymous codon usage biases in coding regions of human and mouse genomes.Genome research · 2002Article
- Origin and evolution of the mitochondrial proteome.Microbiology and molecular biology reviews : MMBR · 2000Review
- Gradients in nucleotide and codon usage along Escherichia coli genes.Nucleic acids research · 2000Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Codon usage and base composition in sequences from the A + T-rich genome of Rickettsia prowazekii, a member of the alpha Proteobacteria, have been investigated. Synonymous codon usage patterns are roughly similar among genes, even though the data set includes genes expected to be expressed at very different levels, indicating that translational selection has been ineffective in this species. However, multivariate statistical analysis differentiates genes according to their G + C contents at the first two codon positions. To study this variation, we have compared the amino acid composition patterns of 21 R. prowazekii proteins with that of a homologous set of proteins from Escherichia coli. The analysis shows that individual genes have been affected by biased mutation rates to very different extents: genes encoding proteins highly conserved among other species being the least affected. Overall, protein coding and intergenic spacer regions have G + C content values of 32.5% and 21.4%, respectively. Extrapolation from these values suggests that R. prowazekii has around 800 genes and that 60-70% of the genome may be coding.
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