ArticleArchives of environmental contamination and toxicology1996
Free peripheral sulfhydryl groups, CD11/CD18 integrins, and calcium are required in the cadmium and nickel enhancement of human-polymorphonuclear leukocyte adherence.
Article in Archives of environmental contamination and toxicology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 17 citations in OpenAlex.
- Urine cadmium and acute myocardial infarction among never smokers in the Danish Diet, Cancer and Health cohort.Environment international · 2021Article
- Cadmium in Human Diseases: It's More than Just a Mere Metal.Indian journal of clinical biochemistry : IJCB · 2019Review
- The vascular system as a target of metal toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadmium and nickel stimulate the early spontaneous adherence of peripheral human polymorphonuclear leukocytes (PMNs). Formyl-methionylleucylphenylalanine (fMLP) at 0.25 nM inhibited the PMN adherence but was stimulated at 10 or 100 nM. Cadmium or nickel, nullified the FMLP inhibitory effect, and enhanced the adherence. No clear additive effect was noticed for either metal with fMLP. Blockade of CD11/CD18 receptors abolished the adherence modulatory effect of both fMLP and metals. p-Chloromercuriphenyl sulfonate (PCMPS), at a concentration that blocks peripheral SH groups, did not affect spontaneous adherence, but completely prevented the adherence enhancement caused by cadmium or nickel. Removal of extracellular calcium diminished both the spontaneous and the metal-stimulated adherence. Ryanodine, at a concentration that persistently inactivates ryanodine-sensitive intracellular channels, inhibited spontaneous PMN adherence, but had no effect on the cadmium or nickel induced adherence enhancement. Therefore, the results indicate that cadmium and nickel adherence stimulation depends on constitutive peripheral SH groups, CD11/CD18 integrins and extracellular calcium, but not on intracellular stored-calcium release through ryanodine-sensitive channels (RyRS). In contrast, spontaneous adherence greatly depends on the release of stored calcium through RyRs, and only slightly on extracellular calcium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.