ArticleJournal of molecular evolution1996
The molecular evolution of vertebrate growth hormones: a pattern of near-stasis interrupted by sustained bursts of rapid change.
Article in Journal of molecular evolution, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Pooled it
- Minireview: The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are Not Humans.Molecular endocrinology (Baltimore, Md.) · 2015Review
- Evolutionary dynamics of Rh2 opsins in birds demonstrate an episode of accelerated evolution in the New World warblers (Setophaga).Molecular ecology · 2015Article
- Dwarfism and increased adiposity in the gh1 mutant zebrafish vizzini.Endocrinology · 2013Article
- Massive screening of copy number population-scale variation in Bos taurus genome.BMC genomics · 2013Article
- The chimpanzee GH locus: composition, organization, and evolution.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Placental expression of pituitary hormones is an ancestral feature of therian mammals.EvoDevo · 2011Article
- Article
- Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Evolution of growth hormone in primates: the GH gene clusters of the New World monkeys marmoset (Callithrix jacchus) and white-fronted capuchin (Cebus albifrons).Journal of molecular evolution · 2006Article
- Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse.Genome research · 2004Article
- Episodic molecular evolution of pituitary growth hormone in Cetartiodactyla.Journal of molecular evolution · 2004Article
- Applications of selective neutrality tests to molecular ecology.Molecular ecology · 2002Review
- Statistical methods for detecting molecular adaptation.Trends in ecology & evolution · 2000Article
- Genomic evolution during a 10,000-generation experiment with bacteria.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Nonsynonymous substitution in abalone sperm fertilization genes exceeds substitution in introns and mitochondrial DNA.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Correlation between the substitution rate and rate variation among sites in protein evolution.Genetics · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been demonstrated previously that in mammals the evolution of pituitary growth hormone shows an unusual pattern, with an underlying slow rate and at least two sustained bursts of rapid evolution (in the artiodactyls and primates), during which the rate increased at least 25-fold. It is demonstrated here that a similar pattern applies for growth hormone evolution throughout the vertebrates, with a basal rate similar to that seen in mammals, but bursts of rapid evolution in the amphibia and the elasmobranchs, and several bursts in the teleosts. The placental growth-hormone-like proteins of primates show a similar pattern. It is argued that the bursts of evolution seen for growth hormone are a consequence of selection and that this may reflect changes in the functions of the hormone additional to its basic growth-promoting actions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.