ArticleAnnals of the rheumatic diseases1996
Association of two loci on chromosome 2q with nodal osteoarthritis.
Article in Annals of the rheumatic diseases, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Osteoarthritis susceptibility loci defined by genome scan meta-analysis.Rheumatology international · 2006Pooled it
- Osteoarthritis susceptibility loci defined by genome scan meta-analysis.Rheumatology international · 2006Pooled it
- Interpositional Arthroplasty Using Mammary Capsule for Finger Joints: A Novel Technique.Plastic and reconstructive surgery. Global open · 2020Article
- Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.BMC medical genetics · 2010Article
- Genetic polymorphisms of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86-bpVNTR) in susceptibility to knee osteoarthritis in a Chinese Han population.Rheumatology international · 2009Article
- BMP receptor signaling is required for postnatal maintenance of articular cartilage.PLoS biology · 2004Article
- Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study.Annals of the rheumatic diseases · 2004Article
- Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3.American journal of human genetics · 2003Article
- Osteoarthritis: understanding the pathophysiology, genetics, and treatments.Journal of the National Medical Association · 2003Review
- Investigation of chromosome 2q in osteoarthritis of the hand: no significant linkage in a Tasmanian population.Annals of the rheumatic diseases · 2002Article
- The role of structural genes in the pathogenesis of osteoarthritic disorders.Arthritis research · 2002Review
- Genetic markers of osteoarticular disorders: facts and hopes.Arthritis research · 2001Review
- Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q.American journal of human genetics · 1999Article
- Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage.American journal of human genetics · 1999Article
- Evidence for genetic anticipation in nodal osteoarthritis.Annals of the rheumatic diseases · 1998Article
- Allelic variation in the vitamin D receptor, lifestyle factors and lumbar spinal degenerative disease.Annals of the rheumatic diseases · 1998Article
- Epidemiology of peripheral joint osteoarthritis.Annals of the rheumatic diseases · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo search for genetic association between microsatellite marker loci and sibling pairs with nodal osteoarthritis (NOA).
methodsUsing the affected sibling pair method of analysis, genomic DNA from 66 sib pairs with NOA was analysed for association with highly polymorphic microsatellite marker loci. The microsatellite markers were amplified using polymerase chain reaction and typed on polyacrylamide gels.
resultsA significant association (p < 0.05) was identified between NOA and two loci on the short arm of chromosome 2 (2q 23-35). Candidate genes for osteoarthritis in this region include: fibronectin, a glycoprotein present in the extracellular matrix of normal cartilage; the alpha 2 chain of collagen type V, a major constituent of bone; and the interleukin-8 receptor, important in the regulation of neutrophil activation and chemotaxis.
conclusionsThe chromosomal region 2q 23-35 requires further detailed study in NOA. Confirmation of these findings in large independent data sets and further analysis of candidate genes in this region will be important in unravelling the molecular basis for this common disease.
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