ReviewArchives of disease in childhood1996
The role of Epstein-Barr virus in Hodgkin's disease from different geographical areas.
Review in Archives of disease in childhood, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 112 citations in OpenAlex.
- Increased Expression of CXCL9, CXCL10, and CXCL11 in Epstein-Barr Virus-Associated Infectious Mononucleosis and the Role of CXCL5 as a Candidate Biomarker of Disease Severity.Pathogens (Basel, Switzerland) · 2026Article
- Article
- The validation of advanced-stage Hodgkin lymphoma international prognostic index (A-HIPI) in Turkish patients with classical Hodgkin lymphoma.Annals of hematology · 2025Article
- Evaluation of plasma Epstein-Barr virus DNA as a biomarker for Epstein-Barr virus-associated Hodgkin lymphoma.SAGE open medicine · 2021Article
- Review
- Genetics of blood malignancies among Iranian population: an overview.Diagnostic pathology · 2020Review
- Prevalence of Epstein–Barr Virus Genotypes in Pakistani Lymphoma PatientsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Latent membrane protein 1 (LMP1) expression in Hodgkin lymphoma and its correlation with clinical and histologic parameters.World journal of surgical oncology · 2017Article
- Cancer of childhood in sub-Saharan Africa.Ecancermedicalscience · 2017Review
- EBV may be expressed in the LP cells of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) in both children and adults.The American journal of surgical pathology · 2014Article
- Epidemiological Overview of Hodgkin Lymphoma across the Mediterranean Basin.Mediterranean journal of hematology and infectious diseases · 2014Review
- 11. Cancers attributable to infection in the UK in 2010.British journal of cancer · 2011Article
- Hodgkin disease and the role of the immune system.Pediatric hematology and oncology · 2011Review
- Characterization of Kaposi's Sarcoma-Associated Herpesvirus-Related Lymphomas by DNA Microarray Analysis.Leukemia research and treatment · 2011Article
- Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.PloS one · 2011Article
- Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt.Journal of hematopathology · 2010Article
- EBV in Hodgkin Lymphoma.Mediterranean journal of hematology and infectious diseases · 2009Article
- Infection and cervical neoplasia: facts and fiction.International journal of clinical and experimental pathology · 2009Article
- Association of Hodgkin's lymphoma with Epstein Barr virus infection.Bosnian journal of basic medical sciences · 2007Article
- The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil.Virchows Archiv : an international journal of pathology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have suggested that Epstein-Barr virus (EBV) may play a role in the aetiology of Hodgkin's disease. To determine the role of EBV in childhood Hodgkin's disease in different geographical areas, immunohistochemical staining and in situ hybridisation were used to analyse latent membrane protein 1 (LMP 1) and small nuclear non-transcribed RNAs (EBER-1) respectively. Testing for EBV within the Reed-Sternberg and Hodgkin's cells was carried out in childhood Hodgkin's disease from 10 different countries. The proportion of LMP 1 positive cases varied significantly, being 50% of cases from the United Kingdom (38/75), South Africa (9/18), Egypt (7/14), and Jordan (8/16), 60% from the United Arab Emirates (6/10), 70% from Australia (11/16), 81% from Costa Rica (34/42), 88% from Iran (7/8), 90% from Greece (20/22), and 100% of the 56 cases from Kenya. A sensitive polymerase chain reaction based EBV strain typing technique was established using archival tissues. EBV strain type 1 was shown to be predominant in childhood Hodgkin's disease from the United Kingdom, South Africa, Australia, and Greece. Type 2 was predominant in Egypt. EBV strain types 1 and 2 were both detected in some cases of childhood Hodgkin's disease in the United Kingdom, Costa Rica, and Kenya. The high incidence of EBV and the presence especially in developing countries of dual infection with both strain types 1 and 2 may reflect socioeconomic conditions leading to malnutrition induced immunological impairment. The possibility of HIV infection also needs to be explored.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.