ArticleAmerican journal of human genetics1996
Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 108 citations in OpenAlex.
- Article
- Review
- Genome-wide phylogenetic analysis and expansion of gene families involved in detoxification in Smittia aterrima (Meigen)and Smittia pratorum (Goetghebuer) (Diptera, Chironomidae).BMC genomic data · 2024Article
- The human ATP-binding cassette (ABC) transporter superfamily.Human mutation · 2022Review
- ABCG2 inhibition as a therapeutic approach for overcoming multidrug resistance in cancer.Journal of biosciences · 2016Review
- Macrophage-mediated cholesterol handling in atherosclerosis.Journal of cellular and molecular medicine · 2016Review
- Association between ABCG1 polymorphism rs1893590 and high-density lipoprotein (HDL) in an asymptomatic Brazilian population.Molecular biology reports · 2015Article
- High-density lipoprotein and atherosclerosis: Roles of lipid transporters.World journal of cardiology · 2014Review
- Whole-genome survey of the putative ATP-binding cassette transporter family genes in Vitis vinifera.PloS one · 2013Article
- Regulation of drug transporters in the testis by environmental toxicant cadmium, steroids and cytokines.Spermatogenesis · 2012Article
- Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in the silkworm, Bombyx mori.Molecular biology reports · 2012Article
- The ABCG family of membrane-associated transporters: you don't have to be big to be mighty.British journal of pharmacology · 2011Review
- ABCG transporters and disease.The FEBS journal · 2011Review
- Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster.Genetics · 2010Article
- Emerging new paradigms for ABCG transporters.Biochimica et biophysica acta · 2009Review
- ABCG transporters: structure, substrate specificities and physiological roles : a brief overview.Journal of bioenergetics and biomembranes · 2007Review
- Article
- ATP-binding cassette, subfamily G (ABCG family).Pflugers Archiv : European journal of physiology · 2007Review
- Cloning of ABCA17, a novel rodent sperm-specific ABC (ATP-binding cassette) transporter that regulates intracellular lipid metabolism.The Biochemical journal · 2005Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an effort to contribute to the transcript map of human chromosome 21 and the understanding of the pathophysiology of trisomy 21, we have used exon trapping to identify fragments of chromosome 21 genes. Two trapped exons, from pools of chromosome 21-specific cosmids, showed homology to the Drosophila white (w) gene. We subsequently cloned the corresponding cDNA for a human homologue of the Drosophila w gene (hW) from human retina and fetal brain cDNA libraries. The gene belongs to the ATP-binding cassette transporter gene family and is homologous to Drosophila w (and to w genes from other species) and to a lesser extent to Drosophila brown (bw) and scarlet (st) genes that are all involved in the transport of eye pigment precursor molecules. A DNA polymorphism with 62% heterozygosity due to variation of a poly (T) region in the 3' UTR of the hW has been identified and used for the incorporation of this gene to the genetic map of chromosome 21. The hW is located at 21q22.3 between DNA markers D21S212 and D21S49 in a P1 clone that also contains marker BCEI. The gene is expressed at various levels in many human tissues. The contributions of this gene to the Down syndrome phenotypes, to human eye color, and to the resulting phenotypes of null or missense mutations are presently unknown.
Indexed as
Identifiers
8659545PMC1915121W1528016198What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.