ArticleAmerican journal of human genetics1996
Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in allergic bronchopulmonary aspergillosis.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- Pooled it
- Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report.The Journal of pediatrics · 2008Guideline
- CFTR mutations and genotypic patterns among cystic fibrosis patients with allergic bronchopulmonary aspergillosis: analysis from a tertiary care center in Saudi Arabia.Frontiers in pediatrics · 2026Article
- Diseases Common in Persons With Cystic Fibrosis Among CFTR Heterozygotes.JAMA internal medicine · 2025Article
- Occurrence of Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations in Patients with Allergic Bronchopulmonary Aspergillosis Complicating Asthma.Mycopathologia · 2022Article
- Clinical Phenotypes of Cystic Fibrosis Carriers.Annual review of medicine · 2022Review
- Cystic fibrosis carriers are at increased risk for a wide range of cystic fibrosis-related conditions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- CARD9Nature immunology · 2018Article
- Aspergillus Species in Bronchiectasis: Challenges in the Cystic Fibrosis and Non-cystic Fibrosis Airways.Mycopathologia · 2018Review
- Allergic Bronchopulmonary Aspergillosis: A Perplexing Clinical Entity.Allergy, asthma & immunology research · 2016Review
- Allergic Bronchopulmonary Aspergillosis Presenting as Recurrent Mass-like Consolidation.Tuberculosis and respiratory diseases · 2015Article
- Allergic aspergillosis of the respiratory tract.European respiratory review : an official journal of the European Respiratory Society · 2014Review
- Impact of heterozygote CFTR mutations in COPD patients with chronic bronchitis.Respiratory research · 2014Article
- Fungal allergy in asthma-state of the art and research needs.Clinical and translational allergy · 2014Article
- The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa.BMC physiology · 2012Article
- Association of CFTR gene mutation with bronchial asthma.The Indian journal of medical research · 2012Review
- A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease.PloS one · 2012Article
- Impact of Aspergillus fumigatus in allergic airway diseases.Clinical and translational allergy · 2011Article
- Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses.American journal of respiratory cell and molecular biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
The etiology of allergic bronchopulmonary aspergillosis (ABPA) is not well understood. A clinical phenotype resembling the pulmonary disease seen in cystic fibrosis (CF) patients can occur in some individuals with ABPA. Reports of familial occurrence of ABPA and increased incidence in CF patients suggest a possible genetic basis for the disease. To test this possibility, the entire coding region of the cystic fibrosis transmembrane regulator (CFTR) gene was analyzed in 11 individuals who met strict criteria for the diagnosis of ABPA and had normal sweat electrolytes (< or = 40 mmol/liter). One patient carried two CF mutations (deltaF508/R347H), and five were found to carry one CF mutation (four deltaF508; one R117H). The frequency of the deltaF508 mutation in patients with ABPA was significantly higher than in 53 Caucasian patients with chronic bronchitis (P < .0003) and the general population (P < .003). These results suggest that CFTR plays an etiologic role in a subset of ABPA patients.
Indexed as
Identifiers
8659542PMC1915108W1909128047What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.