Trial reportAmerican journal of human genetics1996
Cystic fibrosis carrier population screening in the primary care setting.
Trial report in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychological interventions for individuals with cystic fibrosis and their families.The Cochrane database of systematic reviews · 2014Pooled it
- Cystic fibrosis prenatal screening in genetic counseling practice: recommendations of the National Society of Genetic Counselors.Journal of genetic counseling · 2005Guideline
- Attitudes and opinions of pregnant women who are not offered cystic fibrosis carrier screening.European journal of human genetics : EJHG · 2014Trial
- Attitudes of cystic fibrosis patients and parents toward carrier screening and related reproductive issues.European journal of human genetics : EJHG · 2016Article
- A review of consanguinity in Ireland--estimation of frequency and approaches to mitigate risks.Irish journal of medical science · 2016Review
- "Suddenly Having two Positive People who are Carriers is a Whole New Thing" - Experiences of Couples Both Identified as Carriers of Cystic Fibrosis Through a Population-Based Carrier Screening Program in Australia.Journal of genetic counseling · 2015Article
- 'No thanks'-reasons why pregnant women declined an offer of cystic fibrosis carrier screening.Journal of community genetics · 2014Article
- Attitudes of health care professionals toward carrier screening for cystic fibrosis. A review of the literature.Journal of community genetics · 2014Article
- The changing landscape of carrier screening: expanding technology and options?.Health matrix (Cleveland, Ohio : 1991) · 2013Article
- Carrier screening in preconception consultation in primary care.Journal of community genetics · 2012Article
- Genetic testing likelihood: the impact of abortion views and quality of life information on women's decisions.Journal of genetic counseling · 2011Article
- Preconceptional ancestry-based carrier couple screening for cystic fibrosis and haemoglobinopathies: what determines the intention to participate or not and actual participation?European journal of human genetics : EJHG · 2009Article
- A targeted population carrier screening program for severe and frequent genetic diseases in Israel.European journal of human genetics : EJHG · 2009Article
- Parents' perceptions of functioning in families having a child with a genetic condition.Journal of genetic counseling · 2007Article
- Attitudes toward cystic fibrosis carrier and prenatal testing and utilization of carrier testing among relatives of individuals with cystic fibrosis.Journal of genetic counseling · 1999Article
- Prenatal screening for cystic fibrosis carriers: an economic evaluation.American journal of human genetics · 1998Article
- The new genetics. Implications for clinical services in Britain and the United States.BMJ (Clinical research ed.) · 1998Review
- PCR-based screening for cystic fibrosis carrier mutations in an ethnically diverse pregnant population.American journal of human genetics · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
To determine the receptivity of prenatal care providers and their patients to carrier testing for cystic fibrosis (CF), we offered free carrier screening, followed by genetic counseling of carriers, to all prenatal care providers in Rochester, NY, for all their female patients of reproductive age, pregnant or not. Of 124 prenatal care providers, only 37 elected to participate, but many of these offered screening only to pregnant women. The acceptance rate among pregnant women was approximately 57%. The most common reasons for accepting screening were to obtain reassurance (50.7%) and to avoid having a child with CF (27.8 %). The most common reasons for declining screening were not intending to terminate a pregnancy for CF (32.4%) and believing that the chance of having a CF child was very low (32.2%). Compared with decliners, acceptors were more likely to have no children, regarded having a child with CF as more serious, believed themselves more susceptible to having such a child, knew more about CF, would be more likely to terminate a pregnancy if the fetus were shown to have CF, and more strongly supported offering CF screening to women of reproductive age. Of 4,879 women on whom results were obtained, 124 were found to be carriers. Of these 124 carriers, the partners of 106 were tested. Of the five at-risk couples, four requested prenatal diagnosis and one requested neonatal diagnosis. No woman found to be a carrier whose partner tested negative requested prenatal diagnosis. Except for the imperfect knowledge of those testing negative, none of the adverse outcomes predicted for CF carrier testing in the general population were observed in this study.
Indexed as
Identifiers
8659530PMC1915087What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.