ArticleAmerican journal of human genetics1996
Association between nondisjunction and maternal age in meiosis-II human oocytes.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Review
- Maternal uniparental disomy of chromosome 15 with concurrent paternal non-chromosome 15 marker chromosome: a rare presentation of prader-willi syndrome.Molecular cytogenetics · 2025Article
- Single nucleotide polymorphism array (SNP-array) analysis for fetuses with abnormal nasal bone.Archives of gynecology and obstetrics · 2024Article
- Oocyte Health and Quality: Implication of Mitochondria-related Organelle Interactions.Results and problems in cell differentiation · 2024Review
- Factors associated with nonsyndromic anotia and microtia, Texas, 1999-2014.Birth defects research · 2023Article
- Trisomy 21 and Assisted Reproductive Technologies: A review.JBRA assisted reproduction · 2022Review
- Some of the Factors Involved in Male Infertility: A Prospective Review.International journal of general medicine · 2020Review
- Zw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytes.Histochemistry and cell biology · 2019Article
- Can cytoplasmic donation rescue aged oocytes?Reproductive medicine and biology · 2019Review
- Evidence that growth hormone can improve mitochondrial function in oocytes from aged mice.Reproduction (Cambridge, England) · 2018Article
- Loss of Centromere Cohesion in Aneuploid Human Oocytes Correlates with Decreased Kinetochore Localization of the Sac Proteins Bub1 and Bubr1.Scientific reports · 2017Article
- Delayed intracytoplasmic sperm injection (ICSI) with trophectoderm biopsy and preimplantation genetic screening (PGS) show increased aneuploidy rates but can lead to live births with single thawed euploid embryo transfer (STEET).Journal of assisted reproduction and genetics · 2016Article
- Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothers.BMC genetics · 2016Article
- Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.Human reproduction (Oxford, England) · 2016Article
- 1(st) trimester miscarriage: four decades of study.Translational pediatrics · 2015Review
- OMICS: Current and future perspectives in reproductive medicine and technology.Journal of human reproductive sciences · 2014Review
- Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes.PloS one · 2014Article
- Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age.Obstetrics & gynecology science · 2013Article
- Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?Journal of assisted reproduction and genetics · 2011Review
- Association between amino acid turnover and chromosome aneuploidy during human preimplantation embryo development in vitro.Molecular human reproduction · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between advanced maternal age and increased risk of trisomic offspring is well known clinically but not clearly understood at the level of the oocyte. A total of 383 oocytes that failed fertilization from 107 patients undergoing in vitro fertilization were analyzed by FISH using X-, 18-, and 13/21-chromosome probes simultaneously. The corresponding polar bodies were also analyzed in 188 of these oocytes. The chromosomes in the oocyte and first polar body complement each other and provide an internal control to differentiate between aneuploidy and technical errors. Two mechanisms of nondisjunction were determined. First, nondisjunction of bivalent chromosomes resulting in two univalents going to the same pole and, second, nondisjunction by premature chromatid separation (predivision) of univalent chromosomes producing either a balanced (2 + 2) or unbalanced (3 + 1) distribution of chromatids into the first polar body and M-II oocytes. Balanced predivision of chromatids, previously proposed as a major mechanism of aneuploidy, was found to increase significantly with time in culture (P < .005), which suggests that this phenomenon should be interpreted carefully. Unbalanced predivision and classical nondisjunction were unaffected by oocyte aging. In comparing oocytes from women <35 years of age with oocytes from women > or = 40 years of age, a significant increase (P < .001) in nondisjunction of full dyads was found in the oocytes with analyzable polar bodies and no FISH errors. Premature predivision of chromatids was also found to cause nondisjunction, but it did not increase with maternal age.
Indexed as
Identifiers
8659524PMC1915131What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.