ArticleMolecular and cellular biology1996
Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 113 citations in OpenAlex.
- Laboratory-based inequity in thrombosis and hemostasis: review of the evidence.Research and practice in thrombosis and haemostasis · 2023Review
- Role of Nuclear Receptors in Controlling Erythropoiesis.International journal of molecular sciences · 2022Review
- Gender Difference in the Associations among Heavy Metals with Red Blood Cell Hemogram.International journal of environmental research and public health · 2021Article
- Protective role of estrogen against excessive erythrocytosis in Monge's disease.Experimental & molecular medicine · 2021Article
- Review
- Tamoxifen erythroid toxicity revealed by studying the role of nuclear receptor co-activator 4 in erythropoiesis.Haematologica · 2019Article
- The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis.Frontiers in endocrinology · 2019Review
- Life history written in blood: erythrocyte parameters in a small hibernator, the edible dormouse.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Six2 is involved in GATA1-mediated cell apoptosis in mouse embryonic kidney-derived cell lines.In vitro cellular & developmental biology. Animal · 2017Article
- Article
- The use of haemoglobin concentrations to assess physiological condition in birds: a review.Conservation physiology · 2015Review
- Identification of NuRSERY, a new functional HDAC complex composed by HDAC5, GATA1, EKLF and pERK present in human erythroid cells.The international journal of biochemistry & cell biology · 2014Article
- Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.Nature · 2014Article
- Ex-vivo expansion of red blood cells: how real for transfusion in humans?Blood reviews · 2012Review
- Cell signaling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis.Cellular signalling · 2011Article
- Blood in a dish: In vitro synthesis of red blood cells.Drug discovery today. Disease mechanisms · 2011Article
- MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells.Endocrinology · 2010Article
- Advances in the understanding of haemoglobin switching.British journal of haematology · 2010Review
- Humanized culture medium for clinical expansion of human erythroblasts.Cell transplantation · 2010Article
- Identification of ERbeta1 and ERbeta2 in human seminoma, in embryonal carcinoma and in their adjacent intratubular germ cell neoplasia.Reproductive biology and endocrinology : RB&E · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Steroid hormones regulate diverse biological functions, including programmed cell death (apoptosis). Although steroid receptors have been studied extensively, relatively little is known regarding the cellular targets through which apoptosis is triggered. We show here that the ligand-activated estrogen receptor (ER) induces apoptosis in an erythroid cell line by binding to, and consequently inhibiting the activity of, GATA-1, an erythroid transcription factor essential for the survival and maturation of erythroid precursor cells. GATA-1 inhibition is reflected in the downregulation of presumptive GATA-1 target genes. Constitutive overexpression of a GATA-binding protein resistant to the effects of the ER partially rescues ER-induced apoptosis. Induction of apoptosis by a mutant ER defective in binding to the estrogen response element but active in GATA-1 inhibition suggests that ER-mediated inhibition of GATA-1 is direct and does not require estrogen response element-dependent transcriptional activation. Thus, a lineage-restricted transcription factor, such as GATA-1, constitutes one cellular target through which steroid hormones may control apoptosis. As GATA-binding proteins are evolutionarily conserved, we speculate that members of the steroid receptor family may exert some of their diverse biological functions in different cellular contexts through interference with the function of GATA-binding proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.