ArticleMolecular and cellular biology1996
Transcriptional corepression in vitro: a Mot1p-associated form of TATA-binding protein is required for repression by Leu3p.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- A proteomics analysis of yeast Mot1p protein-protein associations: insights into mechanism.Molecular & cellular proteomics : MCP · 2008Article
- ScoC and SinR negatively regulate epr by corepression in Bacillus subtilis.Journal of bacteriology · 2006Article
- Helicase89B is a Mot1p/BTAF1 homologue that mediates an antimicrobial response in Drosophila.EMBO reports · 2005Article
- High-affinity DNA binding by a Mot1p-TBP complex: implications for TAF-independent transcription.The EMBO journal · 2003Article
- Leucine biosynthesis in fungi: entering metabolism through the back door.Microbiology and molecular biology reviews : MMBR · 2003Review
- Mot1 associates with transcriptionally active promoters and inhibits association of NC2 in Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- Mot1p is essential for TBP recruitment to selected promoters during in vivo gene activation.The EMBO journal · 2002Article
- Mot1 activates and represses transcription by direct, ATPase-dependent mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth.Molecular and cellular biology · 2000Article
- Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme.Molecular and cellular biology · 1998Article
- Molecular genetics of the RNA polymerase II general transcriptional machinery.Microbiology and molecular biology reviews : MMBR · 1998Review
- Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1.Molecular and cellular biology · 1998Article
- The yeast TAF145 inhibitory domain and TFIIA competitively bind to TATA-binding protein.Molecular and cellular biology · 1998Article
- A multiplicity of mediators: alternative forms of transcription complexes communicate with transcriptional regulators.Nucleic acids research · 1997Review
- Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme.Molecular and cellular biology · 1997Article
- Evidence that Spt3 functionally interacts with Mot1, TFIIA, and TATA-binding protein to confer promoter-specific transcriptional control in Saccharomyces cerevisiae.Molecular and cellular biology · 1997Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Signals from transcriptional activators to the general mRNA transcription apparatus are communicated by factors associated with RNA polymerase II or the TATA-binding protein (TBP). Currently, little is known about how gene-specific transcription repressors communicate with RNA polymerase II. We have analyzed the requirements for repression by the saccharomyces cerevisiae Leu3 protein (Leu3p) in a reconstituted transcription system. We have identified a complex form of TBP which is required for communication of the repressing signal. This TFIID-like complex contains a known TBP-associated protein, Mot1p, which has been implicated in the repression of a subset of yeast genes by genetic analysis. Leu3p-dependent repression can be reconstituted with purified Mot1p and recombinant TBP. In addition, a mutation in the Mot1 gene leads to partial derepression of the Leu3p-dependent LEU2 promoter. These in vivo and in vitro observations define a role for Mot1p as a transcriptional corepressor.
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