ArticleMolecular and cellular biology1996
Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 114 citations in OpenAlex.
- Computational modeling of chromosome re-replication in mutant strains of fission yeast.Molecular biology of the cell · 2021Article
- The fission yeast S-phase cyclin Cig2 can drive mitosis.Genetics · 2021Article
- CDK Regulation of Meiosis: Lessons fromGenes · 2020Review
- Requirement of PP2A-B56iScience · 2020Article
- Cell cycle transcriptomics of Capsaspora provides insights into the evolution of cyclin-CDK machinery.PLoS genetics · 2020Article
- Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.PloS one · 2018Article
- Article
- Cell cycle control by a minimal Cdk network.PLoS computational biology · 2015Article
- The fission yeast minichromosome maintenance (MCM)-binding protein (MCM-BP), Mcb1, regulates MCM function during prereplicative complex formation in DNA replication.The Journal of biological chemistry · 2013Article
- Article
- Abundance of prereplicative complexes (Pre-RCs) facilitates recombinational repair under replication stress in fission yeast.The Journal of biological chemistry · 2011Article
- Article
- Cyclin-dependent kinase inhibits reinitiation of a normal S-phase program during G2 in fission yeast.Molecular and cellular biology · 2009Article
- Modeling the septation initiation network (SIN) in fission yeast cells.Current genetics · 2007Article
- Cdk phosphorylation of the Ste11 transcription factor constrains differentiation-specific transcription to G1.Genes & development · 2007Article
- Combined analysis reveals a core set of cycling genes.Genome biology · 2007Article
- Pathocycles: Ustilago maydis as a model to study the relationships between cell cycle and virulence in pathogenic fungi.Molecular genetics and genomics : MGG · 2006Review
- The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication.Molecular and cellular biology · 2004Article
- A novel intermediate in initiation complex assembly for fission yeast DNA replication.Molecular biology of the cell · 2004Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cdc2, a catalytic subunit of cyclin-dependent kinases, is required for both the G1-to-S and G2-to-M transitions in the fission yeast Schizosaccharomyces pombe. Cdc13, a B-type cyclin, is required for the M-phase induction function of Cd2. Two additional B-type cyclins, Cig1 and Cig2, have been identified in S. pombe, but none of the B-type cyclins are individually required for the onset of S. We report that Cdc13 is important for DNA replication in a strain lacking Cig2. Unlike deltacdc13 cells, double-mutant deltacdc13 deltacig2 cells are defective in undergoing multiple rounds of DNA replication. The conclusion that Cig2 promotes S is further supported by the finding that Cig2 protein and Cig2-associated kinase activity appear soon after the completion of M and peak during S, as well as the observation that S is delayed in deltacig2 cells as they recover from a G1 arrest induced by nitrogen starvation. These studies indicate that Cig2 is the primary S-phase-promoting cyclin in S. pombe but that Cdc13 can effectively substitute for Cig2 in deltacig2 cells. These observations also suggest that the gradual increase in the activity of Cdc2-Cdc13 kinase can be sufficient for the correct temporal ordering of S and M phases in deltacig2 cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.