ArticleMolecular and cellular biology1996
Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 99 citations in OpenAlex.
- Regulation and Function of the Atypical IκBs-Bcl-3, IκBEuropean journal of immunology · 2025Review
- Regulation of IkappaB Protein Expression by Early Gestation in the Thymus of Ewes.Veterinary sciences · 2023Article
- Aplysia Neurons as a Model of Alzheimer's Disease: Shared Genes and Differential Expression.Journal of molecular neuroscience : MN · 2022Article
- Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation.Frontiers in immunology · 2022Review
- NF-κB and Its Regulators During Pregnancy.Frontiers in immunology · 2021Review
- The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis.Carcinogenesis · 2020Review
- Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.Molecular cell · 2017Article
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- Review
- Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma.PloS one · 2013Article
- Role of T cell-nuclear factor κB in transplantation.Transplantation reviews (Orlando, Fla.) · 2012Review
- NF-κB, the first quarter-century: remarkable progress and outstanding questions.Genes & development · 2012Review
- Role of Bcl-3 in solid tumors.Molecular cancer · 2011Review
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- Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3.PloS one · 2011Article
- Structure-function relationship of cytoplasmic and nuclear IκB proteins: an in silico analysis.PloS one · 2010Article
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- High expression of BCL3 in human myeloma cells is associated with increased proliferation and inferior prognosis.European journal of haematology · 2009Article
- NF-kappaB regulation: the nuclear response.Journal of cellular and molecular medicine · 2009Review
- Bcl-3, a multifaceted modulator of NF-kappaB-mediated gene transcription.Immunologic research · 2008Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have indicated that Bcl-3 interacts through its ankyrin repeats with the transcriptional factors NF-kappaB1 (p50) and NF-kappaB2 (p52), affecting their biological activities. To further investigate the role of Bcl-3 in vivo and its association with the NF-kappaB proteins, we have generated transgenic mice constitutively expressing Bcl-3 in thymocytes. The results indicate that Bcl-3 is associated with endogenous p50 and p52 in nuclear extracts from transgenic animals. Remarkably, constitutive expression of Bcl-3 in these cells augments the DNA binding activity of p52 homodimers. This effect could be reproduced in vitro and is blocked by anti-Bcl-3 antibodies. We have also shown that Bcl-3 is phosphorylated in thymocytes and that its dephosphorylation greatly decreases the effect on p50 homodimers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.