ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Visual stimulation regulates the expression of transcription factors and modulates the composition of AP-1 in visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 73 citations in OpenAlex.
- Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus.Nature communications · 2025Article
- Stress-induced c-fos expression in the medial prefrontal cortex differentially affects the main residing cell phenotypes.Heliyon · 2024Article
- Identification of the Neural Correlates Underlying Conflict Resolution Performance Using a Rodent Analogue of the Stroop Tests.Neuroscience · 2023Article
- Functional correlates of immediate early gene expression in mouse visual cortex.Peer community journal · 2022Article
- Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation.Nature communications · 2021Article
- Rapid and active stabilization of visual cortical firing rates across light-dark transitions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Use of TAI-FISH to visualize neural ensembles activated by multiple stimuli.Nature protocols · 2018Article
- Matrix metalloproteinase (MMP) 9 transcription in mouse brain induced by fear learning.The Journal of biological chemistry · 2013Article
- Article
- Dual activity maps in primate visual cortex produced by different temporal patterns of zif268 mRNA and protein expression.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory.Learning & memory (Cold Spring Harbor, N.Y.)Article
- Tactile experience induces c-fos expression in rat barrel cortex.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is believed that long-term changes in neuronal function are orchestrated by transcription factors, such as AP-1 and ZIF 268, which are in turn regulated by synaptic stimulation. To further our understanding of the functional effects of such expression, we have examined the DNA-binding activities of both AP-1 and ZIF 268 by way of electrophoretic mobility shift assays (EMSA) on nuclear extracts from visual cortices of rats treated with selective light exposure. Visual stimulation after dark rearing increased the DNA-binding activities of both AP-1 and ZIF 268 to their highest levels within 2 hr. ZIF 268 thereafter dropped to levels similar to that observed in naive animals, whereas AP-1 DNA-binding activity continued to remain elevated even after 24 hr of stimulation. The components of the AP-1 complex, when assessed by EMSA-supershift analysis, showed considerable variability under different conditions of exposure. FosB and JunD were the major constituents of AP-1 in both naive and dark-reared animals. Brief visual stimulation (2 hr) added c-Fos, c-Jun, and JunB to this complex, whereas prolonged stimulation (6-24 hr) reduced c-Fos and c-Jun levels significantly, leaving only FosB, JunB, and JunD as the major components of AP-1. These results suggest that transcriptional control by AP-1 may be generated by selective combinatorial interactions of different members of the Fos and Jun families and that are guided by activity-dependent processes.
Indexed as
Identifiers
8656291PMC6578611W2099357519What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.