ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Nerve growth factor (NGF)-mediated protection of neural crest cells from antimitotic agent-induced apoptosis: the role of the low-affinity NGF receptor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 87 citations in OpenAlex.
- Developmentally relevant proteins contribute to chemotherapeutic resistance in neuroblastoma.Frontiers in oncology · 2026Review
- Bovine Lactoferrin Promotes Neurite Outgrowth in PC12 Cells via the TrkA Receptor.International journal of molecular sciences · 2024Article
- The Tangential Dialogue Between Science and Medicine: A Case in Point.Pediatric neurology · 2024Review
- Permeability and distribution of nerve growth factor in the brain of neonatal rats by periphery venous injection in hypoxic-ischemic state.SpringerPlus · 2016Article
- Cerebellar Purkinje cell p75 neurotrophin receptor and autistic behavior.Translational psychiatry · 2014Article
- p75 neurotrophin receptor and fenretinide-induced signaling in neuroblastoma.Cancer chemotherapy and pharmacology · 2014Article
- Novel small molecule activators of the Trk family of receptor tyrosine kinases.Biochimica et biophysica acta · 2013Review
- Aiming at neuroblastoma and hitting other worthy targets.Journal of child neurology · 2013Review
- Why our patients (and we) need basic science research.Neurology · 2013Article
- p75NTR: an enhancer of fenretinide toxicity in neuroblastoma.Cancer chemotherapy and pharmacology · 2013Article
- Necdin and neurotrophin receptors: interactors of relevance for neuronal resistance to oxidant stress.Pediatric research · 2011Article
- Dependence receptors: mechanisms of an announced death.Cell cycle (Georgetown, Tex.) · 2010Article
- Necdin and TrkA contribute to modulation by p75NTR of resistance to oxidant stress.Experimental cell research · 2009Article
- p75NTR-dependent modulation of cellular handling of reactive oxygen species.Journal of neurochemistry · 2009Article
- Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity.Chemistry & biology · 2009Article
- New approaches to pharmacotherapy of tumors of the nervous system during childhood and adolescence.Pharmacology & therapeutics · 2009Review
- p75(NTR)-immunoreactivity in the subventricular zone of adult male rats: expression by cycling cells.Journal of molecular histology · 2004Article
- The common neurotrophin receptor p75NTR enhances the ability of PC12 cells to resist oxidative stress by a trkA-dependent mechanism.Neurotoxicity research · 2001Article
- A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Up-regulation of insulin-like growth factor-II expression is a feature of TrkA but not TrkB activation in SH-SY5Y neuroblastoma cells.The American journal of pathology · 1999Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Prevention by nerve growth factor (NGF) of apoptotic death in neural cells has been variously ascribed to binding of NGF to its low-affinity (p75) or high-affinity (trkA) receptor or to a cooperative interaction between the two. In a series of studies using, in turn, neuroblastoma cell lines that express only p75, mutant NGF species that bind selectively to either p75 or trkA, and a polyclonal antibody that binds to the NGF-binding domain of p75, we demonstrate that NGF binding to p75 is both necessary and sufficient for the abrogation of apoptosis in neuroblastoma cells treated with antimitotic agents.
Indexed as
Identifiers
8656283PMC6578614W2098406368What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.