ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 158 citations in OpenAlex.
- Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress.microPublication biology · 2024Article
- Activity-Dependent Global Downscaling of Evoked Neurotransmitter Release across Glutamatergic Inputs inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Dscam2 suppresses synaptic strength through a PI3K-dependent endosomal pathway.The Journal of cell biology · 2020Article
- Disruptive variants ofScience advances · 2019Article
- Resveratrol-Inspired Bridged Bicyclic Compounds: A New Compound Class for the Protection of Synaptic Function from Acute Oxidative Stress.ACS chemical neuroscience · 2019Article
- The PDZ-GEF Gef26 regulates synapse development and function via FasII and Rap1 at the Drosophila neuromuscular junction.Experimental cell research · 2019Article
- Pseudopterosin A: Protection of Synaptic Function and Potential as a Neuromodulatory Agent.Marine drugs · 2016Article
- Article
- Transmission, Development, and Plasticity of Synapses.Genetics · 2015Review
- Heat shock response and homeostatic plasticity.Frontiers in cellular neuroscience · 2015Article
- The role of cAMP in synaptic homeostasis in response to environmental temperature challenges and hyperexcitability mutations.Frontiers in cellular neuroscience · 2015Article
- Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction.Molecular and cellular neurosciences · 2014Article
- Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response.Developmental neurobiology · 2014Article
- Analysis of various physiological salines for heart rate, CNS function, and synaptic transmission at neuromuscular junctions in Drosophila melanogaster larvae.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
- Retrograde bone morphogenetic protein signaling shapes a key circadian pacemaker circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Neuron-type specific functions of DNT1, DNT2 and Spz at the Drosophila neuromuscular junction.PloS one · 2013Article
- Regulation of Fasciclin II and synaptic terminal development by the splicing factor beag.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The genetic analysis of functional connectomics in Drosophila.Advances in genetics · 2012Review
- Expression of human FUS protein in Drosophila leads to progressive neurodegeneration.Protein & cell · 2011Article
- TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a new test of the hypothesis that synaptic strength is directly related to nerve terminal morphology through analysis of synaptic transmission at Drosophila neuromuscular junctions with a genetically reduced number of nerve terminal varicosities. Synaptic transmission would decrease in target cells with fewer varicosities if there is a relationship between the number of varicosities and the strength of synaptic transmission. Animals that have an extreme hypomorphic allele of the gene for the cell adhesion molecule Fasciclin II possess fewer synapse-bearing nerve terminal varicosities; nevertheless, synaptic strength is maintained at a normal level for the muscle cell as a whole. Fewer failures of neurotransmitter release and larger excitatory junction potentials from individual varicosities, as well as more frequent spontaneous release and larger quantal units, provide evidence for enhancement of transmitter release from varicosities in the mutant. Ultrastructural analysis reveals that mutant nerve terminals have bigger synapses with more active zones per synapse, indicating that synaptic enlargement and an accompanying increase in synaptic complexity provide for more transmitter release at mutant varicosities. These results show that morphological parameters of transmitting nerve terminals can be adjusted to functionally compensate for genetic perturbations, thereby maintaining optimal synaptic transmission.
Indexed as
Identifiers
8656281PMC6578607W2106349285What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.