ArticleThe Journal of cell biology1996
Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Cholecystokinin Outcome on Markers of Intestinal IgA Antibody Response.Current issues in molecular biology · 2022Article
- Article
- TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells.Molecular biology of the cell · 2014Article
- Streptococcus pneumoniae infection of host epithelial cells via polymeric immunoglobulin receptor transiently induces calcium release from intracellular stores.The Journal of biological chemistry · 2011Article
- A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.Nature cell biology · 2010Article
- Identification of a cytoplasmic signal for apical transcytosis.Traffic (Copenhagen, Denmark) · 2009Article
- Cdc42 and the phosphatidylinositol 3-kinase-Akt pathway are essential for PspC-mediated internalization of pneumococci by respiratory epithelial cells.The Journal of biological chemistry · 2009Article
- Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells.American journal of physiology. Cell physiology · 2008Article
- Antibodies to the polymeric immunoglobulin receptor with different binding and trafficking patterns.American journal of respiratory cell and molecular biology · 2005Article
- Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Coupling of histamine H3 receptors to neuronal Na+/H+ exchange: a novel protective mechanism in myocardial ischemia.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Transduction of basolateral-to-apical signals across epithelial cells: ligand-stimulated transcytosis of the polymeric immunoglobulin receptor requires two signals.Molecular biology of the cell · 1999Article
- Article
- The influence of nerves on the secretion of immunoglobulin A into submandibular saliva in rats.The Journal of physiology · 1998Article
- Sorting mechanisms regulating membrane protein traffic in the apical transcytotic pathway of polarized MDCK cells.The Journal of cell biology · 1998Article
- Epithelial transcytosis of immunoglobulins.Journal of mammary gland biology and neoplasia · 1998Review
- Role of tyrosine phosphorylation in ligand-induced regulation of transcytosis of the polymeric Ig receptor.Molecular biology of the cell · 1998Article
- Dimerization of the polymeric immunoglobulin receptor controls its transcytotic trafficking.Molecular biology of the cell · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Many membrane traffic events that were previously thought to be constitutive recently have been found to be regulated by a variety of intracellular signaling pathways. The polymeric immunoglobulin receptor (pIgR) transcytoses dimeric IgA (dIgA) from the basolateral to the apical surface of polarized epithelial cells. Transcytosis is stimulated by binding of dIgA to the pIgR, indicating that the pIgR can transduce a signal to the cytoplasmic machinery responsible for membrane traffic. We report that dIgA binding to the pIgR causes activation of protein kinase C (PKC) and release of inositol 1,4,5-trisphosphate (IP3). The IP3 causes an elevation of intracellular Ca. Artificially activating PKC with phorbol myristate acetate or poisoning the calcium pump with thapsigargin stimulates transcytosis of pIgR, while the intracellular Ca chelator BAPTA-AM inhibits transcytosis. Our data suggest that ligand-induced signaling by the pIgR may regulate membrane traffic via well-known second messenger pathways involving PKC, IP3, and Ca. This may be a model of a general means by which membrane traffic is regulated by receptor-ligand interaction and signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.