ArticleThe Journal of cell biology1996
Subunit composition of neurofilaments specifies axonal diameter.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Neurofilament Light Chain and Multiple Sclerosis: Building a Neurofoundational Model of Biomarkers and Diagnosis.Neurology international · 2025Article
- Neurofilament Biophysics: From Structure to Biomechanics.Molecular biology of the cell · 2024Review
- Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation.Nature neuroscience · 2024Article
- Prediction of Outcome After Endovascular Embolectomy in Anterior Circulation Stroke Using Biomarkers.Translational stroke research · 2022Article
- Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA.Science translational medicine · 2021Article
- Cytoskeletal organization of axons in vertebrates and invertebrates.The Journal of cell biology · 2020Article
- Neuroprotein Targets of γ-Diketone Metabolites of Aliphatic and Aromatic Solvents That Induce Central-Peripheral Axonopathy.Toxicologic pathology · 2020Review
- Microtubule Imaging Reveals Cytoskeletal Deficit Predisposing the Retinal Ganglion Cell Axons to Atrophy in DBA/2J.Investigative ophthalmology & visual science · 2018Article
- Article
- Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells.The Journal of nutrition · 2017Article
- Exacerbation of Charcot-Marie-Tooth type 2E neuropathy following traumatic nerve injury.Brain research · 2015Article
- Neuronal and glia-related biomarkers in cerebrospinal fluid of patients with acute ischemic stroke.Journal of central nervous system disease · 2014Article
- Conformational properties of interacting neurofilaments: Monte Carlo simulations of cylindrically grafted apposing neurofilament brushes.Journal of biological physics · 2013Article
- Expansion of neurofilament medium C terminus increases axonal diameter independent of increases in conduction velocity or myelin thickness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Expressing hNF-LE397K results in abnormal gaiting in a transgenic model of CMT2E.Genes, brain, and behavior · 2012Article
- The role of stretching in slow axonal transport.Biophysical journal · 2011Article
- The polymer brush model of neurofilament projections: effect of protein composition.Biophysical journal · 2010Article
- Gel-expanded to gel-condensed transition in neurofilament networks revealed by direct force measurements.Nature materials · 2010Article
- A novel recessive Nefl mutation causes a severe, early-onset axonal neuropathy.Annals of neurology · 2009Article
- The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.Cerebellum (London, England) · 2009Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Neurofilaments (NFs), which are composed of NF-L, NF-M, and NF-H, are required for the development of normal axonal caliber, a property that in turn is a critical determinant of axonal conduction velocity. To investigate how each subunit contributes to the radial growth of axons, we used transgenic mice to alter the subunit composition of NFs. Increasing each NF subunit individually inhibits radial axonal growth, while increasing both NF-M and NF-H reduces growth even more severely. An increase in NF-L results in an increased filament number but reduced interfilament distance. Conversely, increasing NF-M, NF-H, or both reduces filament number, but does not alter nearest neighbor interfilament distance. Only a combined increase of NF-L with either NF-M or NF-H promotes radial axonal growth. These results demonstrate that both NF-M and NF-H play complementary roles with NF-L in determining normal axonal calibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.