ArticleThe Journal of cell biology1996
Constitutive expression of the machinery for programmed cell death.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 384 citations in OpenAlex.
- Article
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- The Effects of Capsaicin on Gastrointestinal Cancers.Molecules (Basel, Switzerland) · 2020Review
- Role of Extrinsic Apoptotic Signaling Pathway during Definitive Erythropoiesis in Normal Patients and in Patients with β-Thalassemia.International journal of molecular sciences · 2020Review
- Temporal analysis of the autophagic and apoptotic phenotypes inMicrobial cell (Graz, Austria) · 2018Article
- 3D matrix-embedding inhibits cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis of human endothelial cells.Journal of tissue engineering and regenerative medicine · 2018Article
- Manipulating the mitochondria activity in human hepatic cell line Huh7 by low-power laser irradiation.Biomedical optics express · 2018Article
- Staurosporine Induces the Generation of Polyploid Giant Cancer Cells in Non-Small-Cell Lung Carcinoma A549 Cells.Analytical cellular pathology (Amsterdam) · 2018Article
- Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons.Oxidative medicine and cellular longevity · 2017Article
- Laser-assisted hatching of cleavage-stage embryos impairs developmental potential and increases DNA damage in blastocysts.Lasers in medical science · 2015Article
- Nanoparticles for localized delivery of hyaluronan oligomers towards regenerative repair of elastic matrix.Acta biomaterialia · 2013Article
- Laser microbeam-induced DNA damage inhibits cell division in fertilized eggs and early embryos.Cell cycle (Georgetown, Tex.) · 2013Article
- Mitochondrial thiols in the regulation of cell death pathways.Antioxidants & redox signaling · 2012Review
- Article
- DNA alteration and programmed cell death during ageing of sunflower seed.Journal of experimental botany · 2011Article
- Prevention of apoptosis by the interaction between FIH1 and Bax.Molecular and cellular biochemistry · 2011Article
- Aging is associated with a proapoptotic endothelial progenitor cell phenotype.Journal of vascular research · 2011Article
- Androgens selectively protect against apoptosis in hippocampal neurones.Journal of neuroendocrinology · 2010Article
- Analysis of host- and strain-dependent cell death responses during infectious salmon anemia virus infection in vitro.Virology journal · 2009Article
- Involvement of all-trans-retinal in acute light-induced retinopathy of mice.The Journal of biological chemistry · 2009Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the presence of cycloheximide (CHX) to inhibit protein synthesis, a high concentration of staurosporine (STS) induces almost all cells in explant cultures of 8/8 types of newborn mouse organs and 3/3 types of adult mouse organs to die with the characteristic features of apoptosis. Eggs and blastomeres also die in this way when treated with STS and CHX, although they are less sensitive to this treatment than trophectoderm or inner cell mass cells whose sensitivity resembles that of other developing cells. Human red blood cells are exceptional in being completely resistant to treatment with STS and CHX. As (STS plus CHX)-induced cell deaths have been shown to display the characteristic features of programmed cell death (PCD), we conclude that all mammalian nucleated cells are capable of undergoing PCD and constitutively express all the proteins required to do so. It seems that the machinery for PCD is in place and ready to run, even though its activation often depends on new RNA and protein synthesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.