ArticleJournal of bacteriology1996
Evidence that the hanA gene coding for HU protein is essential for heterocyst differentiation in, and cyanophage A-4(L) sensitivity of, Anabaena sp. strain PCC 7120.
Article in Journal of bacteriology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Nitrogen availability shapes evolution of phage resistance in cyanobacteria.The ISME journal · 2025Article
- Tradeoffs between phage resistance and nitrogen fixation drive the evolution of genes essential for cyanobacterial heterocyst functionality.The ISME journal · 2024Article
- Inactivation of Three RG(S/T)GR Pentapeptide-Containing Negative Regulators of HetR Results in Lethal Differentiation ofLife (Basel, Switzerland) · 2020Article
- The regulation of HanA during heterocyst development in cyanobacterium Anabaena sp. PCC 7120.World journal of microbiology & biotechnology · 2014Article
- Unraveling the redox properties of the global regulator FurA from Anabaena sp. PCC 7120: disulfide reductase activity based on its CXXC motifs.Antioxidants & redox signaling · 2014Article
- Article
- Cell surface-associated proteins in the filamentous cyanobacterium Anabaena sp. strain PCC 7120.Microbes and environments · 2012Article
- Site-specific recombination in the cyanobacterium Anabaena sp. strain PCC 7120 catalyzed by the integrase of coliphage HK022.Journal of bacteriology · 2009Article
- Different functions of HetR, a master regulator of heterocyst differentiation in Anabaena sp. PCC 7120, can be separated by mutation.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Flexible DNA bending in HU-DNA cocrystal structures.The EMBO journal · 2003Article
- Novel DNA-binding proteins in the cyanobacterium Anabaena sp. strain PCC 7120.Journal of bacteriology · 2002Article
- Regulation of cellular differentiation in filamentous cyanobacteria in free-living and plant-associated symbiotic growth states.Microbiology and molecular biology reviews : MMBR · 2002Review
- HcwA, an autolysin, is required for heterocyst maturation in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2001Article
- Identification and inactivation of three group 2 sigma factor genes in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2001Article
- The hetF gene product is essential to heterocyst differentiation and affects HetR function in the cyanobacterium Nostoc punctiforme.Journal of bacteriology · 2001Article
- Nitrogen control in cyanobacteria.Journal of bacteriology · 2001Review
- An overview of the genome of Nostoc punctiforme, a multicellular, symbiotic cyanobacterium.Photosynthesis research · 2001Article
- Effect on heterocyst differentiation of nitrogen fixation in vegetative cells of the cyanobacterium Anabaena variabilis ATCC 29413.Journal of bacteriology · 2001Article
- Regulation of hepA of Anabaena sp. strain PCC 7120 by elements 5' from the gene and by hepK.Journal of bacteriology · 1998Article
- hetC, a gene coding for a protein similar to bacterial ABC protein exporters, is involved in early regulation of heterocyst differentiation in Anabaena sp. strain PCC 7120.Journal of bacteriology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The highly pleiotropic, transposon-generated mutant AB22 of Anabaena sp. strain PCC 7120 exhibits slow growth, altered pigmentation, cellular fragility, resistance to phage A-4(L), and the inability to differentiate heterocysts. Reconstruction of the transposon mutation in the wild-type strain reproduced the phenotype of the original mutant. Sequencing of the flanking DNA showed that the transposon had inserted at the beginning of a gene, which we call hanA, that encodes Anabaena HU protein (R. Nagaraja and R. Haselkorn, Biochimie 76:1082-1089, 1994). Mapping of the transposon insertion by pulsed-field gel electrophoresis showed that hanA is located at ca. 4.76 Mb on the physical map of the chromosome and is transcribed clockwise. Repeated subculturing of AB22 resulted in improved growth and loss of filament fragmentation, presumably because of one or more compensatory mutations; however, the mutant retained its A-4(L)r Het- phenotype. The mutation in strain AB22 could be complemented by a fragment of wild-type DNA bearing hanA as its only open reading frame.
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