ArticleHuman genetics1996
Distribution of mosaicism in human placentae.
Article in Human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 72 citations in OpenAlex.
- Interdependence of placenta and fetal cardiac development.Prenatal diagnosis · 2024Review
- Article
- Unexpected finding of uniparental disomy mosaicism in term placentas: Is it a common feature in trisomic placentas?Prenatal diagnosis · 2018Article
- Pervasive polymorphic imprinted methylation in the human placenta.Genome research · 2016Article
- Chromosomal Mosaicism in Human Feto-Placental Development: Implications for Prenatal Diagnosis.Journal of clinical medicine · 2014Review
- Bioinformatic Tools Identify Chromosome-Specific DNA Probes and Facilitate Risk Assessment by Detecting Aneusomies in Extra-embryonic Tissues.Current genomics · 2012Article
- Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation.Human reproduction (Oxford, England) · 2012Article
- Placenta-specific expression of the interleukin-2 (IL-2) receptor β subunit from an endogenous retroviral promoter.The Journal of biological chemistry · 2011Article
- Somatic genomic variations in extra-embryonic tissues.Current genomics · 2010Article
- Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia.Journal of medical genetics · 2006Article
- Comparative genomic hybridization in combination with flow cytometry improves results of cytogenetic analysis of spontaneous abortions.American journal of human genetics · 2000Article
- Skewed X-chromosome inactivation is common in fetuses or newborns associated with confined placental mosaicism.American journal of human genetics · 1997Article
- Meiotic origin of trisomy in confined placental mosaicism is correlated with presence of fetal uniparental disomy, high levels of trisomy in trophoblast, and increased risk of fetal intrauterine growth restriction.American journal of human genetics · 1997Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional first trimester chorionic villus sampling (CVS) for prenatal diagnosis can be performed by cytogenetic analysis of cytotrophoblast or chorionic villous stroma. Approximately 2% of pregnancies studied by CVS show confined placental mosaicism (CPM) involving either cytotrophoblast, stroma or both. We present the results of a cytogenetic study of nine term placentae from pregnancies with prenatally diagnosed CPM. The aneuploid++ cell lines involved trisomies for chromosomes 7,9,16, and X. The cytotrophoblast and villous stroma from multiple biopsies of these placentae were examined using a combination of interphase and metaphase cytogenetic analysis. CPM was detected in all nine of the term placentae and both tissue-specific and site-specific patterns of mosaicism could be discerned. These results indicate that the analysis of villous stroma and cytotrophoblast from multiple placental biopsies is necessary to improve our understanding of the evolution of CPM during pregnancy and its effect on the fetus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.