ArticleHuman genetics1996
Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia.
Article in Human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- Genetic endophenotypes for insomnia of major depressive disorder and treatment-induced insomnia.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis.Current medical science · 2018Pooled it
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Effect of polymorphisms of three genes mediating monoamine signalling on brain morphometry in schizophrenia and healthy subjects.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2015Article
- Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits.PloS one · 2015Article
- Candidate gene associations with withdrawn behavior.Journal of child psychology and psychiatry, and allied disciplines · 2013Article
- The CC genotype in the T102C HTR2A polymorphism predicts relapse in individuals after alcohol treatment.Journal of psychiatric research · 2013Article
- Serotonin 2A Receptor Gene Polymorphism in Korean Children with Attention-Deficit/Hyperactivity Disorder.Psychiatry investigation · 2012Article
- The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients.Journal of psychiatric research · 2012Article
- Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB.The international journal of neuropsychopharmacology · 2010Article
- SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.Psychiatric genetics · 2009Article
- Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- 5-HT2A receptor density is decreased in the at-risk mental state.Psychopharmacology · 2008Article
- Antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia: associations with dopamine and serotonin receptor and transporter polymorphisms.European journal of clinical pharmacology · 2007Article
- Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample.Journal of neural transmission (Vienna, Austria : 1996) · 2007Article
- Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.American journal of human genetics · 2006Article
- Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients.Clinical rheumatology · 2004Article
- Molecular genetics of schizophrenia: past, present and future.Journal of biosciences · 2002Review
- Family-based association study of the serotonin-2A receptor gene (5-HT2A) and bipolar disorder.Neuromolecular medicine · 2002Article
- Effects of phencyclidine (PCP) and MK 801 on the EEGq in the prefrontal cortex of conscious rats; antagonism by clozapine, and antagonists of AMPA-, alpha(1)- and 5-HT(2A)-receptors.British journal of pharmacology · 2002Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
A statistically significant association between a silent mutation (102T/C) in the serotonin-2A (5-HT2A) receptor gene and schizophrenia has recently been reported in a sample of Japanese patients and healthy controls. This finding suggests that genetic predisposition to schizophrenia may be affected by a functional 5-HT2A receptor variant that is in linkage disequilibrium with 102T/C. In the present study, we have sought to identify genetic variation in the 5-HT2A receptor gene by screening genomic DNA samples from 91 unrelated subjects comprising 45 patients with schizophrenia and 46 healthy controls by using single-strand conformation analysis. We have identified four nucleotide sequence variants. Two sequence changes would result in protein alterations: a substitution of threonine by asparagine at position 25 (Thr25Asn), and a substitution of histidine by tyrosine at position 452 (His452Tyr). In order to test for a possible contribution to the development of schizophrenia, we have determined allele frequencies in extended samples of unrelated patients and healthy controls. The two amino acid substitutions are found with similar frequencies in patients and controls, indicating that the presence of these variants is not causally related to the development of schizophrenia. However, the reported association of the non-coding polymorphism 102T/C with the disease has also been detected in our sample (P=0.041, odds ratio=1.28, 95% confidence interval 1.012-1.623).
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