ArticleHuman genetics1996
Differential underacetylation of histones H2A, H3 and H4 on the inactive X chromosome in human female cells.
Article in Human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A Hypothesis: Linking Phase Separation to Meiotic Sex Chromosome Inactivation and Sex-Body Formation.Frontiers in cell and developmental biology · 2021Review
- Lysine acetylation regulates the activity of nuclear Pif1.The Journal of biological chemistry · 2020Article
- Histone variant H3.3 orchestrates neural stem cell differentiation in the developing brain.Cell death and differentiation · 2017Article
- Incorporation of 5-ethynyl-2'-deoxyuridine (EdU) as a novel strategy for identification of the skewed X inactivation pattern in balanced and unbalanced X-rearrangements.Human genetics · 2016Article
- Review
- Finding a balance: how diverse dosage compensation strategies modify histone h4 to regulate transcription.Genetics research international · 2012Article
- A scaffold for X chromosome inactivation.Human genetics · 2011Review
- Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation.Development (Cambridge, England) · 2011Article
- Epigenetic modifications on X chromosomes in marsupial and monotreme mammals and implications for evolution of dosage compensation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Restricting dosage compensation complex binding to the X chromosomes by H2A.Z/HTZ-1.PLoS genetics · 2009Article
- Engineered human dicentric chromosomes show centromere plasticity.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Article
- Normal histone modifications on the inactive X chromosome in ICF and Rett syndrome cells: implications for methyl-CpG binding proteins.BMC biology · 2004Article
- Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects.Molecular biology of the cell · 2003Article
- DNA methylation controls histone H3 lysine 9 methylation and heterochromatin assembly in Arabidopsis.The EMBO journal · 2002Article
- Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome.The Journal of cell biology · 2002Article
- Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila.Eukaryotic cell · 2002Article
- Allele-specific underacetylation of histone H4 downstream from promoters is associated with X-inactivation in human cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2002Article
- Histone H4 acetylation of euchromatin and heterochromatin is cell cycle dependent and correlated with replication rather than with transcription.The Plant cell · 2000Article
- Common methylation characteristics of sex chromosomes in somatic and germ cells from mouse, lemur and human.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2000Article
- Versatility of conviction: heterochromatin as both a repressor and an activator of transcription.Genetica · 2000Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
It has previously been shown that the acetylated forms of histone H4 are depleted or absent in both constitutive, centric heterochromatin and in the facultative heterochromatin of the inactive X chromosome (Xi) in female cells. By immunostaining of metaphase chromosomes from human lymphocytes with antibodies to the acetylated isoforms of histones H2A and H3, we now show that these histones too are underacetylated in both Xi and centric heterochromatin. Xi shows two prominent regions of residual H3 acetylation, one encompassing the pseudoautosomal region at the end of the short arm and one at about Xq22. Both these regions have been shown previously to be sites of residual H4 acetylation. H2A acetylation on Xi is higher overall than that of H3 or H4 and is particularly high around the pseudoautosomal region, but not at Xq22. The results suggest that the acetylated isoforms of H3 and H4 have at least some effects on chromosomal structure and function that are not shared by acetylated H2A.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.