ArticleThe EMBO journal1996
A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 55 citations in OpenAlex.
- FUS-DDIT3 prevents the development of adipocytic precursors in liposarcoma by repressing PPARgamma and C/EBPalpha and activating eIF4E.PloS one · 2008Article
- C-fms expression correlates with monocytic differentiation in PML-RAR alpha+ acute promyelocytic leukemia.Leukemia · 2003Article
- Review
- PML protein isoforms and the RBCC/TRIM motif.Oncogene · 2001Review
- The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice.Oncogene · 2000Article
- Article
- Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- TGF-beta cooperates with TGF-alpha to induce the self-renewal of normal erythrocytic progenitors: evidence for an autocrine mechanism.The EMBO journal · 1999Article
- The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.The Journal of clinical investigation · 1998Article
- Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.The Journal of cell biology · 1997Article
- Cell death induction by the acute promyelocytic leukemia-specific PML/RARalpha fusion protein.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cellular localization, expression, and structure of the nuclear dot protein 52.The Journal of cell biology · 1997Article
- Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Myb-Ets fusion oncoprotein inhibits thyroid hormone receptor/c-ErbA and retinoic acid receptor functions: a novel mechanism of action for leukemogenic transformation by E26 avian retrovirus.Molecular and cellular biology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The promyelocyte (PML)-retinoic acid receptor alpha (RARalpha) fusion gene results from a t(15;17) chromosome translocation in acute promyelocytic leukaemia. We have analysed the oncogenic potential of the human fusion PML-RARalpha product in chicken using retrovirus vectors. We show that PML-RARalpha transforms very early haematopoietic progenitor cells in vitro and induces acute leukaemias. Neither PML nor RARalpha domains alone achieve such a transformation. The PML-RARalpha viruses recovered from the transformed cells carry two point mutations in the PML domain, one of which alters both the pattern of intracellular localization of the fusion protein and its functional interference with AP-1, thus defining an essential domain in PML for oncogenic transformation.
Indexed as
Identifiers
8654368PMC450206W238523500What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.