ArticleAnnals of surgery1996
Caloric restriction increases the expression of heat shock protein in the gut.
Article in Annals of surgery, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 58 citations in OpenAlex.
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- Fitness correlates of blubber oxidative stress and cellular defences in grey seals (Halichoerus grypus): support for the life-history-oxidative stress theory from an animal model of simultaneous lactation and fasting.Cell stress & chaperones · 2023Article
- Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?Life (Basel, Switzerland) · 2021Review
- Modelling and analysis of the feeding regimen induced entrainment of hepatocyte circadian oscillators using petri nets.PloS one · 2015Article
- Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans.The Journal of biological chemistry · 2012Article
- Diapause formation and downregulation of insulin-like signaling via DAF-16/FOXO delays axonal degeneration and neuronal loss.PLoS genetics · 2012Article
- Protein homeostasis and aging: The importance of exquisite quality control.Ageing research reviews · 2011Review
- The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies.Brain research reviews · 2009Review
- Chaperones come of age.Cell stress & chaperones · 2002Review
- Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury.Journal of molecular neuroscience : MN · 2001Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe authors determined whether caloric restriction (CR) either acutely or chronically, alters heat shock protein 70 (hsp70) gene expression in the gut. SUMMARY BACKGROUND DATA: Caloric restriction prolongs the life span and delays age-related disease (e.g., cancer) in mammals; the mechanisms responsible for these effects are not known. Heat shock proteins are a group of stress-responsive genes of which the most prominent member is hsp70.
methodsIn the first experiment, adult (4-month-old) rats (n = 3/group) were killed after a 48-hour fast or 6 and 24 hours after refeeding. In addition, three rats (controls) were killed without fasting or refeeding. The stomach was removed and RNA was extracted for hsp70 gene expression. In the second experiment, aged (22- to 26-month-old) rats were fed ad libitum (AL) or a CR diet (60% caloric intake of AL diet). Rats were killed, the stomach and duodenum were removed, and RNA was extracted for determination of hsp70 gene expression.
resultsIn the first experiment, hsp70 mRNA levels were increased approximately threefold in the stomach of rats fasted for 48 hours; levels decreased to control values by 6 and 24 hours after refeeding. In the second experiment, hsp70 mRNA levels were increased significantly in both the stomach and duodenum of aged CR rats compared with AL controls.
conclusionsThe authors have demonstrated that hsp70 mRNA levels are increased in the proximal gut of young and old rats, either acutely (with fasting) or with CR. Increased expression of the cytoprotective hsp70 gene in the gut may provide a possible cellular mechanism for the beneficial effects noted with CR.
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