ArticleAmerican journal of human genetics1996
Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Efficient Estimation of Realized Kinship from Single Nucleotide Polymorphism Genotypes.Genetics · 2017Article
- Identification of novel susceptibility loci for Guam neurodegenerative disease: challenges of genome scans in genetic isolates.Human molecular genetics · 2009Article
- Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms.Journal of vascular surgery · 2005Article
- Discovery of genetic difference between asthmatic children with high IgE level and normal IgE level by whole genome linkage disequilibrium mapping using 763 autosomal STR markers.Journal of human genetics · 2005Article
- Evidence of linkage and association on chromosome 20 for late-onset Alzheimer disease.Neurogenetics · 2004Article
- A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set.American journal of human genetics · 2003Article
- Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The trimmed-haplotype test for linkage disequilibrium.American journal of human genetics · 2000Article
- Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations.American journal of human genetics · 2000Article
- Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility.American journal of human genetics · 1998Article
- Disequilibrium likelihoods for fine-scale mapping of a rare allele.American journal of human genetics · 1998Article
- A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Structure and function of the human Werner syndrome gene promoter: evidence for transcriptional modulation.Nucleic acids research · 1998Article
- Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.American journal of human genetics · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Werner syndrome (WS) is an autosomal recessive disorder characterized by premature onset of a number of age-related diseases. The gene for WS, WRN, has been mapped to the 8p 11.1-21.1 region with further localization through linkage disequilibrium mapping. Here we present the results of linkage disequilibrium and ancestral haplotype analyses of 35 markers to further refine the location of WRN. We identified an interval in this region in which 14 of 18 markers tested show significant evidence of linkage disequilibrium in at least one of the two populations tested. Analysis of extended and partial haplotypes covering 21 of the markers studied supports the existence of both obligate and probable ancestral recombinant events which localize WRN almost certainly to the interval between D8S2196 and D8S2186, and most likely to the narrower interval between D8S2168 and D8S2186. These haplotype analyses also suggest that there are multiple WRN mutations in each of the two populations under study. We also present a comparison of approaches to performing disequilibrium tests with multiallelic markers, and show that some commonly used approximations for such tests perform poorly in comparison to exact probability tests. Finally, we discuss some of the difficulties introduced by the high mutation rate at microsatellite markers which influence our ability to use ancestral haplotype analysis to localize disease genes.
Indexed as
Identifiers
8651307PMC1915073What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.