ArticleAmerican journal of human genetics1996
Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 121 citations in OpenAlex.
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.Molecular psychiatry · 2005Trial
- Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families.Molecular psychiatry · 2005Trial
- Genetics of bipolar disorder.Dialogues in clinical neuroscience · 2008Review
- Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3.Molecular psychiatry · 2006Article
- Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains.Genetics · 2005Article
- Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q.American journal of human genetics · 2005Article
- Genetic tests of biologic systems in affective disorders.Molecular psychiatry · 2005Review
- Genetics of major mood disorders.Psychiatry (Edgmont (Pa. : Township)) · 2004Article
- Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12.Molecular psychiatry · 2003Article
- Chromosomal abnormalities and mental illness.Molecular psychiatry · 2003Review
- Review of bipolar molecular linkage and association studies.Current psychiatry reports · 2002Review
- A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3.Molecular psychiatry · 2002Article
- Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.Molecular psychiatry · 2002Article
- Manic-depression genes and the new millennium: poised for discovery.Molecular psychiatry · 2002Review
- Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder.Molecular psychiatry · 2001Article
- A genome screen of a large bipolar affective disorder pedigree supports evidence for a susceptibility locus on chromosome 13q.Molecular psychiatry · 2001Article
- Mutation analysis of SYNJ1: a possible candidate gene for chromosome 21q22-linked bipolar disorder.Molecular psychiatry · 2001Article
- News about disturbances of neuronal migration bring views to bipolar disorder.Molecular psychiatry · 2000Article
- Genetics of bipolar affective disorder.Current psychiatry reports · 2000Review
- Glucocorticoid receptor alpha and beta isoforms are not mutated in bipolar affective disorder.Molecular psychiatry · 2000Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal P values <.01) under two affection-status models, ASM I (bipolars and schizoaffectives) and ASM II (ASM I plus recurrent unipolars). In addition, under ASM I, the proximal interval spanned by D21S1436 and D21S65 showed locus trios with excess allele sharing (nominal P values of .03-.0003). These findings support prior evidence that a susceptibility locus for bipolar disorder is on 21q.
Indexed as
Identifiers
8651306PMC1915054W1589573948What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.