ArticleAmerican journal of human genetics1996
Heritability of X chromosome--inactivation phenotype in a large family.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 176 citations in OpenAlex.
- X-linked competition - implications for human development and disease.Nature reviews. Genetics · 2025Review
- The transcriptional legacy of developmental stochasticity.Nature communications · 2023Article
- Escape from X-inactivation in twins exhibits intra- and inter-individual variability across tissues and is heritable.PLoS genetics · 2023Article
- Variability of cross-tissue X-chromosome inactivation characterizes timing of human embryonic lineage specification events.Developmental cell · 2022Article
- Molecular Mechanisms of Skewed X-Chromosome Inactivation in Female Hemophilia Patients-Lessons from Wide Genome Analyses.International journal of molecular sciences · 2021Article
- Intelligence Quotient Variability in Klinefelter Syndrome Is Associated With GTPBP6 Expression Under Regulation of X-Chromosome Inactivation Pattern.Frontiers in genetics · 2021Article
- Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age.Nature communications · 2019Article
- Α de novo 3.8-Mb inversion affecting the EDA and XIST genes in a heterozygous female calf with generalized hypohidrotic ectodermal dysplasia.BMC genomics · 2019Article
- Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus.Nature communications · 2019Article
- Demonstration of a novel Xp22.2 microdeletion as the cause of familial extreme skewing of X-inactivation utilizing case-parent trio SNP microarray analysis.Molecular genetics & genomic medicine · 2018Article
- Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- X inactivation in females with X-linked Charcot-Marie-Tooth disease.Neuromuscular disorders : NMD · 2012Article
- Inter- and intra-individual variation in allele-specific DNA methylation and gene expression in children conceived using assisted reproductive technology.PLoS genetics · 2010Article
- Expression of the disease on female carriers of X-linked lysosomal disorders: a brief review.Orphanet journal of rare diseases · 2010Review
- X chromosome inactivation in clinical practice.Human genetics · 2009Review
- Non-random X chromosome inactivation in Aicardi syndrome.Human genetics · 2009Article
- Comparison of X-chromosome inactivation patterns in multiple tissues from human females.Journal of medical genetics · 2008Article
- Association of androgen receptor CAG repeat polymorphism and polycystic ovary syndrome.The Journal of clinical endocrinology and metabolism · 2008Article
- No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans.The Journal of clinical investigation · 2008Article
- X-chromosome inactivation patterns in females with Prader-Willi syndrome.American journal of medical genetics. Part A · 2007Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the two X chromosomes in each somatic cell of normal human females becomes inactivated very early in embryonic development. Although the inactivation of an X chromosome in any particular somatic cell of the embryonic lineage is thought to be a stochastic and epigenetic event, a strong genetic influence on this process has been described in the mouse. We have attempted to uncover evidence for genetic control of X-chromosome inactivation in the human by examining X chromosome-inactivation patterns in 255 females from 36 three-generation pedigrees, to determine whether this quantitative character exhibits evidence of heritability. We have found one family in which all seven daughters of one male and the mother of this male have highly skewed patterns of X-chromosome inactivation, suggesting strongly that this quantitative character is controlled by one or more X-linked genes in some families.
Indexed as
Identifiers
8651287PMC1915075W1492806079What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.