ArticleMolecular and cellular biology1996
Nutritional regulation of late meiotic events in Saccharomyces cerevisiae through a pathway distinct from initiation.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Polycomb group (PcG) proteins prevent the assembly of abnormal synaptonemal complex structures during meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- How Boundaries Form: Linked Nonautonomous Feedback Loops Regulate Pattern Formation in Yeast Colonies.Genetics · 2019Article
- Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation.Microbial cell (Graz, Austria) · 2016Article
- Cell Differentiation and Spatial Organization in Yeast Colonies: Role of Cell-Wall Integrity Pathway.Genetics · 2015Article
- Sporulation patterning and invasive growth in wild and domesticated yeast colonies.Research in microbiology · 2010Article
- The Rim101p/PacC pathway and alkaline pH regulate pattern formation in yeast colonies.Genetics · 2010Article
- The Ras/cAMP pathway and the CDK-like kinase Ime2 regulate the MAPK Smk1 and spore morphogenesis in Saccharomyces cerevisiae.Genetics · 2009Article
- Glucose induction pathway regulates meiosis in Saccharomyces cerevisiae in part by controlling turnover of Ime2p meiotic kinase.FEMS yeast research · 2008Article
- Loss of meiotic rereplication block in Saccharomyces cerevisiae cells defective in Cdc28p regulation.Eukaryotic cell · 2005Article
- Glucose inhibits meiotic DNA replication through SCFGrr1p-dependent destruction of Ime2p kinase.Molecular and cellular biology · 2005Article
- Site-specific genomic (SSG) and random domain-localized (RDL) mutagenesis in yeast.BMC biotechnology · 2004Article
- TOR regulates the subcellular localization of Ime1, a transcriptional activator of meiotic development in budding yeast.Molecular and cellular biology · 2003Article
- Lack of mitochondrial citrate synthase discloses a new meiotic checkpoint in a strict aerobe.The EMBO journal · 2002Article
- Meiotic differentiation during colony maturation in Saccharomyces cerevisiae.Current genetics · 2002Article
- CAK1 promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-independent fashion.Molecular and cellular biology · 2002Article
- G1 cyclins block the Ime1 pathway to make mitosis and meiosis incompatible in budding yeast.The EMBO journal · 1999Article
- Reversible association between the V1 and V0 domains of yeast vacuolar H+-ATPase is an unconventional glucose-induced effect.Molecular and cellular biology · 1998Article
- NDT80 and the meiotic recombination checkpoint regulate expression of middle sporulation-specific genes in Saccharomyces cerevisiae.Molecular and cellular biology · 1998Article
- Snf1 kinase connects nutritional pathways controlling meiosis in Saccharomyces cerevisiae.Molecular and cellular biology · 1998Article
- Multiple and distinct activation and repression sequences mediate the regulated transcription of IME1, a transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The IME1 gene is essential for initiation of meiosis in the yeast Saccharomyces cerevisiae, although it is not required for growth. Here we report that in stationary-phase cultures containing low concentration of glucose, cells overexpressing IME1 undergo the early meiotic events, including DNA replication, commitment to recombination, and synaptonemal complex formation and dissolution. In contrast, later meiotic events, such as chromosome segregation, commitment to meiosis, and spore formation, do not occur. Thus, nutrients can repress the late stages of meiosis independently of their block of initiation. Cells arrested at this midpoint in meiosis are relatively stable and can resume meiotic differentiation if transferred to sporulation conditions. Resumption of meiosis does not require repression of IME1 expression, since IME1 RNA levels stay high after transfer of the arrested cells to sporulation medium. These results suggest that meiosis in S. cerevisiae is a paradigm of a differentiation pathway regulated by signal transduction at both early and late stages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.