ArticleMolecular and cellular biology1996
Sex-specific and non-sex-specific oligomerization domains in both of the doublesex transcription factors from Drosophila melanogaster.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 80 citations in OpenAlex.
- A panoramic view of the expression and function of the Doublesex/DMRT gene family inScience advances · 2026Article
- Molecular characterization of transformer, transformer-2, and doublesex genes in the carambola fruit fly, Bactrocera carambolae, revealing potential for genetic pest management.Insect science · 2026Article
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- Article
- DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation.Frontiers in neuroanatomy · 2022Review
- Evolutionary transition of doublesex regulation from sex-specific splicing to male-specific transcription in termites.Scientific reports · 2021Article
- Chemoreceptor Diversity in Apoid Wasps and Its Reduction during the Evolution of the Pollen-Collecting Lifestyle of Bees (Hymenoptera: Apoidea).Genome biology and evolution · 2021Article
- Phylogenetic analysis and embryonic expression of panarthropod Dmrt genes.Frontiers in zoology · 2019Article
- Doublesex Evolution Is Correlated with Social Complexity in Ants.Genome biology and evolution · 2018Article
- Analysis of the genome of the New Zealand giant collembolan (Holacanthella duospinosa) sheds light on hexapod evolution.BMC genomics · 2017Article
- RNA sequencing reveals a complete but an unconventional type of dosage compensation in the domestic silkwormRoyal Society open science · 2017Article
- Asymmetric interactions between doublesex and tissue- and sex-specific target genes mediate sexual dimorphism in beetles.Nature communications · 2017Article
- Double nexus--Doublesex is the connecting element in sex determination.Briefings in functional genomics · 2015Review
- The ubiquity and ancestry of insect doublesex.Scientific reports · 2015Article
- Article
- Characterization of the doublesex gene within the Culex pipiens complex suggests regulatory plasticity at the base of the mosquito sex determination cascade.BMC evolutionary biology · 2015Article
- The role of doublesex in the evolution of exaggerated horns in the Japanese rhinoceros beetle.EMBO reports · 2013Article
- Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes.Insect molecular biology · 2013Article
- Dmrt genes in the development and evolution of sexual dimorphism.Trends in genetics : TIG · 2012Review
- Positive and purifying selection influence the evolution of doublesex in the Anastrepha fraterculus species group.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The doublesex gene of Drosophila melanogaster encodes the alternatively spliced, sex-specific transcription factors DSXM and DSXF. These factors regulate male- and female-specific transcription of many genes. For example, female-specific transcription of the yolk protein 1 gene is regulated by DSXM repression in males and DSXF activation in females. In this study we used in vitro interaction assays and the in vivo yeast two-hybrid method to identify and examine oligomerization domains of the DSX proteins. A 66-amino-acid segment common to both proteins (amino acids 39 to 104) contains a sequence-specific DNA binding domain and an oligomerization domain (OD1). The OD1 domain oligomerizes up to at least a pentamer, but only dimers bound to a palindromic regulatory site in the yolk protein 1 gene are detected. Both subunits of the OD1 dimer are in contact with DNA. Another segment of each protein (amino acids 350 to 412 for DSXF and 350 to 427 for DSXM) contains a second oligomerization domain (OD2F and OD2M, respectively). The OD2 domains have both sex-specific and non-sex-specific sequences which are necessary for oligomerization. On the basis of sequence analysis, we predict that OD2 oligomerizes through coiled-coil interactions. We speculate that the common function of OD1 and OD2 is to oligomerize the full-length proteins, whereas their specialized functions are to form a dimeric DNA binding unit and a sex-specific transcriptional activation or repression unit.
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