ArticleMolecular and cellular biology1996
TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Interactions between the DNA Damage Response and the Telomere Complex in Carcinogenesis: A Hypothesis.Current issues in molecular biology · 2023Review
- TTT (Tel2-Tti1-Tti2) Complex, the Co-Chaperone of PIKKs and a Potential Target for Cancer Chemotherapy.International journal of molecular sciences · 2023Review
- Novel compound heterozygous mutations inOpen life sciences · 2023Article
- Article
- AMolecular and cellular biology · 2019Article
- Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast.PLoS genetics · 2017Article
- Article
- Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.G3 (Bethesda, Md.) · 2016Article
- A Syndromic Intellectual Disability Disorder Caused by Variants in TELO2, a Gene Encoding a Component of the TTT Complex.American journal of human genetics · 2016Article
- Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length.Nature communications · 2015Article
- Genetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae.PloS one · 2012Article
- Quantitative proteomic identification of the BRCA1 ubiquitination substrates.Journal of proteome research · 2011Article
- Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance.BMC systems biology · 2011Article
- Liquid facets-related (lqfR) is required for egg chamber morphogenesis during Drosophila oogenesis.PloS one · 2011Article
- A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.Genes & development · 2010Article
- Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.The Journal of biological chemistry · 2010Article
- ATM-like kinases and regulation of telomerase: lessons from yeast and mammals.Trends in cell biology · 2008Review
- Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Genes & development · 2008Article
- Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.Genome biology · 2008Article
- Differential nuclear localization does not determine the silencing status of Saccharomyces cerevisiae telomeres.Genetics · 2007Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
The DNA-protein complexes at the ends of linear eukaryotic chromosomes are called the telomeres. In Saccharomyces cerevisiae, telomeric DNA consists of a variable length of the short repeated sequence C1-3A. The length of yeast telomeres can be altered by mutation, by changing the levels of telomere binding proteins, or by increasing the amount of C1-3A DNA sequences. Cells bearing the tel1-1 or tel2-1 mutations, known previously to have short telomeres, did not respond to perturbations that caused telomere lengthening in wild-type cells. The transcription of genes placed near yeast telomeres is reversibly repressed, a phenomenon called the telomere position effect. The tel2-1 mutation reduced the position effect but did not affect transcriptional repression at the silent mating type cassettes, HMRa and HML alpha. The TEL2 gene was cloned, sequenced, and disrupted. Cells lacking TEL2 function died, with some cells arresting as large cells with three or four small protrusions or "blebs."
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