ArticleMolecular and cellular biology1996
Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 127 citations in OpenAlex.
- Clinicopathological Analysis of Expression of Enhancer of Zeste Homologue 2 in Canine Mammary Carcinoma.Journal of veterinary research · 2022Article
- Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis.Nature communications · 2022Article
- Ezh2 harnesses the intranuclear actin cytoskeleton to remodel chromatin in differentiating Th cells.iScience · 2021Article
- Article
- Histone Methyltransferase EZH2: A Potential Therapeutic Target for Kidney Diseases.Frontiers in physiology · 2021Review
- EZH2 reduction is an essential mechanoresponse for the maintenance of super-enhancer polarization against compressive stress in human periodontal ligament stem cells.Cell death & disease · 2020Article
- Identification and Expression Pattern of EZH2 in Pig Developing Fetuses.BioMed research international · 2020Article
- EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation.Epigenetics & chromatin · 2018Article
- EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms.Oncogene · 2018Article
- Molecular characterization of EZH2 mutant patients with myelodysplastic/myeloproliferative neoplasms.Leukemia · 2017Article
- EZH2 as a mediator of treatment resistance in melanoma.Pigment cell & melanoma research · 2016Review
- Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma.Neoplasia (New York, N.Y.) · 2016Article
- EZH2 in normal hematopoiesis and hematological malignancies.Oncotarget · 2016Review
- Polycomb repressive complex's evolutionary conserved function: the role of EZH2 status and cellular background.Clinical epigenetics · 2016Review
- Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.Oncotarget · 2015Review
- The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin.Nature immunology · 2015Article
- The functional consequences of variation in transcription factor binding.PLoS genetics · 2014Article
- The Fusarium graminearum histone H3 K27 methyltransferase KMT6 regulates development and expression of secondary metabolite gene clusters.PLoS genetics · 2013Article
- Chromatin targeting drugs in cancer and immunity.Genes & development · 2013Review
- Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression.Epigenetics & chromatin · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in the transcriptional regulation of homeobox genes, known to be important effectors in the hematopoietic system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.