ArticleMolecular and cellular biology1996
Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 118 citations in OpenAlex.
- Kar4 acts as a Ste12 regulator inbioRxiv : the preprint server for biology · 2025Article
- Global Transcriptomic Analysis Identifies Gene Expression Programs Regulated by α-Factor in Yeast.Journal of microbiology and biotechnology · 2025Article
- Basal association of a transcription factor favors early gene expression.PLoS genetics · 2025Article
- A network of transcription factors in complex with a regulating cell cycle cyclin orchestrates fungal oxidative stress responses.BMC biology · 2024Article
- Multidimensional characterization of inducible promoters and a highly light-sensitive LOV-transcription factor.Nature communications · 2023Article
- A yeast cell cycle model integrating stress, signaling, and physiology.FEMS yeast research · 2022Article
- Analysis of the pheromone signaling pathway by RT-qPCR in the budding yeastSTAR protocols · 2022Article
- Hormone analysis and candidate genes identification associated with seed size inRoyal Society open science · 2022Article
- Transcription factor regulatory modules provide the molecular mechanisms for functional redundancy observed among transcription factors in yeast.BMC bioinformatics · 2019Article
- Timing of gene expression in a cell-fate decision system.Molecular systems biology · 2018Article
- Spatial and temporal signal processing and decision making by MAPK pathways.The Journal of cell biology · 2017Review
- Switch-like Transitions Insulate Network Motifs to Modularize Biological Networks.Cell systems · 2016Article
- Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition.Cell · 2015Article
- Review
- Feedforward regulation ensures stability and rapid reversibility of a cellular state.Molecular cell · 2013Article
- m:Explorer: multinomial regression models reveal positive and negative regulators of longevity in yeast quiescence.Genome biology · 2012Article
- Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress.PLoS genetics · 2012Article
- TF-centered downstream gene set enrichment analysis: Inference of causal regulators by integrating TF-DNA interactions and protein post-translational modifications information.BMC bioinformatics · 2010Article
- An overview of Cdk1-controlled targets and processes.Cell division · 2010Article
- Role of the cell wall integrity and filamentous growth mitogen-activated protein kinase pathways in cell wall remodeling during filamentous growth.Eukaryotic cell · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The transcripts of many genes involved in Saccharomyces cerevisiae mating were found to fluctuate during the cell cycle. In the absence of a functional Ste12 transcription factor, both the levels and the cell cycle pattern of expression of these genes were affected. FUS1 and AGA1 levels, which are maximally expressed only in G1-phase cells, were strongly reduced in ste12- cells. The cell cycle transcription pattern for FAR1 was changed in ste12- cells: the gene was still significantly expressed in G2/M, but transcript levels were strongly reduced in G1 phase, resulting in a lack of Far1 protein accumulation. G2/M transcription of FAR1 was dependent on the transcription factor Mcm1, and expression of a gene with Mcm1 fused to a strong transcriptional activation domain resulted in increased levels of FAR1 transcription. The pattern of cell cycle-regulated transcription of FAR1 could involve combinatorial control of Ste12 and Mcm1. Forced G1 expression of FAR1 from the GAL1 promoter resorted the ability to arrest in response to pheromone in ste12-cells. This indicates that transcription of FAR1 in the G1 phase is essential for accumulation of the protein and for pheromone-induced cell cycle arrest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.