ArticleMolecular and cellular biology1996
Participation of the yeast activator Abf1 in meiosis-specific expression of the HOP1 gene.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts.Nucleic acids research · 2023Article
- Genome-wide off-rates reveal how DNA binding dynamics shape transcription factor function.Molecular systems biology · 2020Article
- Finding trans-regulatory genes and protein complexes modulating meiotic recombination hotspots of human, mouse and yeast.BMC systems biology · 2014Article
- Regulated antisense transcription controls expression of cell-type-specific genes in yeast.Molecular and cellular biology · 2011Article
- Global transcriptional response of Saccharomyces cerevisiae to the deletion of SDH3.BMC systems biology · 2009Article
- Genome-wide expression profiling, in vivo DNA binding analysis, and probabilistic motif prediction reveal novel Abf1 target genes during fermentation, respiration, and sporulation in yeast.Molecular biology of the cell · 2008Article
- Swapping the gene-specific and regional silencing specificities of the Hst1 and Sir2 histone deacetylases.Molecular and cellular biology · 2007Article
- Genetic evidence for a SPO1-dependent signaling pathway controlling meiotic progression in yeast.Genetics · 2007Article
- The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase.The EMBO journal · 2004Article
- Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.Microbiology and molecular biology reviews : MMBR · 2004Review
- The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain.Molecular and cellular biology · 2004Article
- Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae.Current genetics · 2003Article
- Article
- Yeast Ume6p repressor permits activator binding but restricts TBP binding at the HOP1 promoter.Nucleic acids research · 2003Article
- Regulation of the premiddle and middle phases of expression of the NDT80 gene during sporulation of Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- Identification of a multifunctional domain in autonomously replicating sequence-binding factor 1 required for transcriptional activation, DNA replication, and gene silencing.Molecular and cellular biology · 2002Article
- Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast.Molecular and cellular biology · 2001Article
- The Sir1 protein's association with a silenced chromosome domain.Genes & development · 2001Article
- Building a dictionary for genomes: identification of presumptive regulatory sites by statistical analysis.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Two genes required for meiotic recombination in Drosophila are expressed from a dicistronic message.Genetics · 2000Article
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Authors and funding
4 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The meiosis-specific gene HOP1, which encodes a component of the synaptonemal complex, is controlled through two regulatory elements, UASH and URS1H. Sites similar to URS1H have been identified in the promoter region of virtually every early meiosis-specific gene, as well as in many promoters of nonmeiotic genes, and it has been shown that the proteins that bind to this site function to regulate meiotic and nonmeiotic transcription. Sites similar to the UASH site have been found in a number of meiotic and nonmeiotic genes as well. Since it has been shown that UASH functions as an activator site in vegetative haploid cells, it seemed likely that the factors binding to this site regulate both meiotic and nonmeiotic transcription. We purified the factor binding to the UASH element of the HOP1 promoter. Sequence analysis identified the protein as Abf1 (autonomously replicating sequence-binding factor 1), a multifunctional protein involved in DNA replication, silencing, and transcriptional regulation. We show by mutational analysis of the UASH site, that positions outside of the proposed UASH consensus sequence (TNTGN[A/T]GT) are required for DNA binding in vitro and transcriptional activation in vivo. A new UASH consensus sequence derived from this mutational analysis closely matches a consensus Abf1 binding site. We also show that an Abf1 site from a nonmeiotic gene can replace the function of the UASH site in the HOP1 promoter. Taken together, these results show that Abf1 functions to regulate meiotic gene expression.
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