ArticleMolecular and cellular biology1996
Repression by HoxA7 is mediated by the homeodomain and the modulatory action of its N-terminal-arm residues.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- Mechanisms Underlying Hox-Mediated Transcriptional Outcomes.Frontiers in cell and developmental biology · 2021Review
- Article
- HoxA Genes and the Fin-to-Limb Transition in Vertebrates.Journal of developmental biology · 2016Review
- HOXB13 is co-localized with androgen receptor to suppress androgen-stimulated prostate-specific antigen expression.Anatomy & cell biology · 2010Article
- Cellular uptake of Antennapedia Penetratin peptides is a two-step process in which phase transfer precedes a tryptophan-dependent translocation.Nucleic acids research · 2003Article
- Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases.Molecular and cellular biology · 2000Article
- Multiple ras downstream pathways mediate functional repression of the homeobox gene product TTF-1.Molecular and cellular biology · 2000Article
- HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis.Oncogene · 2000Article
- PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins.Molecular and cellular biology · 1999Article
- CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein.Oncogene · 1999Article
- CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity.Molecular and cellular biology · 1999Article
- Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hox genes encode homeodomain-containing proteins that are presumed to control spatial patterning during murine embryogenesis through their actions as transcriptional regulatory proteins. In this study, we have investigated the transcriptional function of a prototypic member of this family, HoxA7. We demonstrate that HoxA7 function as a potent transcriptional repressor and that its action as such requires several domains, including both activator and repressor regions. The repressor regions are contained within the homeodomain and a C-terminal acidic region, both of which are well conserved among members of the Hox family. Accordingly, we show that two other members of this family also function as repressors, although they vary in their relative repressor potency. Finally, we explore the novel observation that the homeodomain of HoxA7 functions as a transcriptional repressor domain. We show that the homeodomain compared with two other DNA-binding domains, is unique in its ability to function as a repressor domain and that repression requires conserved residues, in helix III. We further show that residues in the N-terminal arm of the homeodomain contribute to the differential repressor actions of various Hox proteins. These findings demonstrate that the transcriptional function of HoxA7 and possibility of Hox proteins in general is determined by their unique combination of conserved and nonconserved regions as well as through the complex actions of their homeodomains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.