ArticleMolecular and cellular biology1996
BRO1, a novel gene that interacts with components of the Pkc1p-mitogen-activated protein kinase pathway in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 68 citations in OpenAlex.
- The Bro1-like domain-containing protein, AtBro1, modulates growth and abiotic stress responses in Arabidopsis.Frontiers in plant science · 2023Article
- MaAts, an Alkylsulfatase, Contributes to Fungal Tolerances against UV-B Irradiation and Heat-Shock inJournal of fungi (Basel, Switzerland) · 2022Article
- EhADH112 is a Bro1 domain-containing protein involved in the Entamoeba histolytica multivesicular bodies pathway.Journal of biomedicine & biotechnology · 2012Article
- The synthetic genetic network around PKC1 identifies novel modulators and components of protein kinase C signaling in Saccharomyces cerevisiae.Eukaryotic cell · 2008Article
- Article
- Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway.Eukaryotic cell · 2007Article
- Article
- Widespread cytoplasmic mRNA transport in yeast: identification of 22 bud-localized transcripts using DNA microarray analysis.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Up-regulation of ALG-2 in hepatomas and lung cancer tissue.The American journal of pathology · 2003Article
- YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix.Molecular and cellular biology · 2003Article
- Article
- Regulation of gene expression by ambient pH in filamentous fungi and yeasts.Microbiology and molecular biology reviews : MMBR · 2002Review
- Osmotic stress signaling and osmoadaptation in yeasts.Microbiology and molecular biology reviews : MMBR · 2002Review
- Genetic control of extracellular protease synthesis in the yeast Yarrowia lipolytica.Genetics · 2002Article
- Yeast PalA/AIP1/Alix homolog Rim20p associates with a PEST-like region and is required for its proteolytic cleavage.Journal of bacteriology · 2001Article
- Suppressors of ssy1 and ptr3 null mutations define novel amino acid sensor-independent genes in Saccharomyces cerevisiae.Genetics · 2001Article
- A genomic approach for the identification and classification of genes involved in cell wall formation and its regulation in Saccharomyces cerevisiae.Comparative and functional genomics · 2001Article
- A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae.The Journal of cell biology · 1999Article
- SWM1, a developmentally regulated gene, is required for spore wall assembly in Saccharomyces cerevisiae.Molecular and cellular biology · 1999Article
- MAP kinase pathways in the yeast Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1998Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yeast cells with mutations in BRO1 display phenotypes similar to those caused by deletion of BCK1, a gene encoding a MEK kinase that functions in a mitogen-activated protein kinase pathway mediating maintenance of cell integrity. bro1 cells exhibit a temperature-sensitive growth defect that is suppressed by the addition of osmotic stabilizers or Ca2+ to the growth medium or by additional copies of the BCK1 gene. At permissive temperatures, bro1 mutants are sensitive to caffeine and respond abnormally to nutrient limitation. A null mutation in BRO1 is synthetically lethal with null mutations in BCK1, MPK1, which encodes a mitogen-activated protein kinase that functions downstream of Bck1p, or PKC1, a gene encoding a protein kinase C homolog that activates Bck1p. Analysis of the isolated BRO1 gene revealed that it encodes a novel, 97-kDa polypeptide which contains a putative SH3 domain-binding motif and is homologous to a protein of unknown function in Caenorhabditis elegans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.